Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

Definition:

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.

References:

[1]. Sarah Donald, et al. P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett. 2004 Aug 13;572(1-3):172-6. [Content Brief]

[2]. Hans Rosenfeldt, et al. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett. 2004 Aug 13;572(1-3):167-71. [Content Brief]

[3]. Raji E Joseph, et al. Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2. J Biol Chem. 2005 Jul 29;280(30):27508-12. [Content Brief]

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