2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. BJJF078

BJJF078 is an aminopiperidine derivative. BJJF078 is a potent inhibitor of recombinant human and mouse Transglutaminase enzyme (TG2) activity, IC50 values of 41 and 54 nM, respectively. BJJF078 also inhibits the close related enzyme TG1, with an IC50 of 0.16 μM. BJJF078 can be used for Multiple sclerosis (MS) research.

For research use only. We do not sell to patients.

BJJF078 Chemical Structure

BJJF078 Chemical Structure

CAS No. : 2531244-56-9

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1 mg USD 60 In-stock
5 mg USD 132 In-stock
10 mg USD 188 In-stock
25 mg USD 320 In-stock
50 mg USD 475 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BJJF078 is an aminopiperidine derivative. BJJF078 is a potent inhibitor of recombinant human and mouse Transglutaminase enzyme (TG2) activity, IC50 values of 41 and 54 nM, respectively. BJJF078 also inhibits the close related enzyme TG1, with an IC50 of 0.16 μM. BJJF078 can be used for Multiple sclerosis (MS) research[1].

IC50 & Target

IC50: 41 nM (hTG2), 54 nM (mTG2), 0.16 μM (TG1)[1]
Molecular Weight

523.60

Formula

C27H29N3O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1CCN(S(=O)(C2=C3C=CC=C(NC(C4=CC=C(C(OC)=C4)OC)=O)C3=CC=C2)=O)CC1)C=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (238.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9099 mL 9.5493 mL 19.0985 mL
5 mM 0.3820 mL 1.9099 mL 3.8197 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9099 mL 9.5493 mL 19.0985 mL 47.7464 mL
5 mM 0.3820 mL 1.9099 mL 3.8197 mL 9.5493 mL
10 mM 0.1910 mL 0.9549 mL 1.9099 mL 4.7746 mL
15 mM 0.1273 mL 0.6366 mL 1.2732 mL 3.1831 mL
20 mM 0.0955 mL 0.4775 mL 0.9549 mL 2.3873 mL
25 mM 0.0764 mL 0.3820 mL 0.7639 mL 1.9099 mL
30 mM 0.0637 mL 0.3183 mL 0.6366 mL 1.5915 mL
40 mM 0.0477 mL 0.2387 mL 0.4775 mL 1.1937 mL
50 mM 0.0382 mL 0.1910 mL 0.3820 mL 0.9549 mL
60 mM 0.0318 mL 0.1592 mL 0.3183 mL 0.7958 mL
80 mM 0.0239 mL 0.1194 mL 0.2387 mL 0.5968 mL
100 mM 0.0191 mL 0.0955 mL 0.1910 mL 0.4775 mL
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BJJF078 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BJJF0782531244-56-9BJJF 078BJJF-078GlutaminaseAminopiperidineTransglutaminaseTG1TG2multiple sclerosisexperimental autoimmune encephalomyelitisInhibitorinhibitorinhibit

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