2. Autophagy Apoptosis
  3. Autophagy Apoptosis
  4. BKN-1

BKN-1 is a bifunctional ligand that can not only track the formation of mtG4s (G-quadruplexes, four-stranded DNA structures containing Hoogsteen bonds) through far-red emission, but can also induce mitochondrial dysfunction. BKN-1 has anti-tumor activity and may cause mtDNA loss, damage mitochondrial integrity, reduce ATP levels, and trigger ROS imbalance, leading to apoptosis and autophagy.

For research use only. We do not sell to patients.

BKN-1 Chemical Structure

BKN-1 Chemical Structure

CAS No. : 1607831-82-2

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BKN-1 Related Antibodies

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Description

BKN-1 is a bifunctional ligand that can not only track the formation of mtG4s (G-quadruplexes, four-stranded DNA structures containing Hoogsteen bonds) through far-red emission, but can also induce mitochondrial dysfunction. BKN-1 has anti-tumor activity and may cause mtDNA loss, damage mitochondrial integrity, reduce ATP levels, and trigger ROS imbalance, leading to apoptosis and autophagy[1].

Molecular Weight

556.48

Formula

C31H29IN2
CAS No.
SMILES

CCN1C2=C(C=C(/C=C/C3=[N+](C)C(C=CC4=C5C=CC=C4)=C5C3(C)C)C=C2)C6=C1C=CC=C6.[I-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BKN-1 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BKN-11607831-82-2BKN1BKN 1AutophagyApoptosisFluorescent ligandG-quadruplexMitochondrial DNAMitochondrial dysfunctionInhibitorinhibitorinhibit

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