2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. BMSpep-57 hydrochloride

BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68?nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs.

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Custom Peptide Synthesis

BMSpep-57 hydrochloride Chemical Structure

BMSpep-57 hydrochloride Chemical Structure

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Other Forms of BMSpep-57 hydrochloride:

BMSpep-57 hydrochloride Related Antibodies

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Description

BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68?nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs[1].

IC50 & Target

IC50: 7.68 nM (PD-1/PD-L1 interaction)[1]
In Vitro

In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300?nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC50 of 7.68?nM[1].
BMSpep-57 induced high levels of IL-2 at 1?μM and 500?nM concentrations in SEB-stimulated peripheral blood mononuclear cells[1].
BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMSpep-57 hydrochloride Related Antibodies
Molecular Weight

1904.63

Formula

C89H127ClN24O19S
Appearance

Solid

Color

White to off-white

Sequence

{mercaptoacetic acid}-Phe-Ala-Asn-Pro-His-Leu-Ser-Trp-Ser-Trp-{norleucine}-{norleucine}-Arg-Cys-Gly (Sulfide bridge:mercaptoacetic acid 1-Cys15)
Sequence Shortening

{mercaptoacetic acid}-FANPHLSWSW-{norleucine}-{norleucine}-RCG (Sulfide bridge:mercaptoacetic acid 1-Cys15)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (52.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5250 mL 2.6252 mL 5.2504 mL
5 mM 0.1050 mL 0.5250 mL 1.0501 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5250 mL 2.6252 mL 5.2504 mL 13.1259 mL
5 mM 0.1050 mL 0.5250 mL 1.0501 mL 2.6252 mL
10 mM 0.0525 mL 0.2625 mL 0.5250 mL 1.3126 mL
15 mM 0.0350 mL 0.1750 mL 0.3500 mL 0.8751 mL
20 mM 0.0263 mL 0.1313 mL 0.2625 mL 0.6563 mL
25 mM 0.0210 mL 0.1050 mL 0.2100 mL 0.5250 mL
30 mM 0.0175 mL 0.0875 mL 0.1750 mL 0.4375 mL
40 mM 0.0131 mL 0.0656 mL 0.1313 mL 0.3281 mL
50 mM 0.0105 mL 0.0525 mL 0.1050 mL 0.2625 mL
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BMSpep-57 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMSpep-57BMSpep57BMSpep 57PD-1/PD-L1PD-1/Programmed death-ligand 1IL-2 productionPBMCdrug-likeimmunologicalPPIInhibitorinhibitorinhibit

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