2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. BMSpep-57

BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50?of 7.68?nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST?and SPR assays, respectively.?BMSpep-57?facilitates T cell function by in creasing IL-2 production in PBMCs.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

BMSpep-57 Chemical Structure

BMSpep-57 Chemical Structure

CAS No. : 1629655-80-6

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Based on 1 publication(s) in Google Scholar

Other Forms of BMSpep-57:

BMSpep-57 Related Antibodies

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Description

BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50?of 7.68?nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST?and SPR assays, respectively.?BMSpep-57?facilitates T cell function by in creasing IL-2 production in PBMCs[1].

IC50 & Target

IC50: 7.68 nM (PD-1/PD-L1 interaction)[1]
In Vitro

In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300?nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC50?of 7.68?nM[1].
BMSpep-57 induced high levels of IL-2 at 1?μM and 500?nM concentrations in ?SEB-stimulated peripheral blood mononuclear cells[1].
BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMSpep-57 Related Antibodies
Molecular Weight

1868.17

Formula

C89H126N24O19S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{mercaptoacetic acid}-Phe-Ala-Asn-Pro-His-Leu-Ser-Trp-Ser-Trp-{norleucine}-{norleucine}-Arg-Cys-Gly (Sulfide bridge:mercaptoacetic acid 1-Cys15)
Sequence Shortening

{mercaptoacetic acid}-FANPHLSWSW-{norleucine}-{norleucine}-RCG (Sulfide bridge:mercaptoacetic acid 1-Cys15)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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BMSpep-57 Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMSpep-571629655-80-6BMSpep57BMSpep 57PD-1/PD-L1PD-1/Programmed death-ligand 1IL-2 productionPBMCdrug-likeimmunologicalInhibitorinhibitorinhibit

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