2. PROTAC
  3. PROTAC Linkers
  4. Boc-NH-C4-Br

Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

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Boc-NH-C4-Br Chemical Structure

Boc-NH-C4-Br Chemical Structure

CAS No. : 164365-88-2

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Based on 1 publication(s) in Google Scholar

Boc-NH-C4-Br Related Antibodies

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Description

Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-NH-C4-Br Related Antibodies
Molecular Weight

252.15

Formula

C9H18BrNO2
CAS No.
Appearance

<30°C Solid,>32°C Liquid

Color

White to off-white

SMILES

O=C(OC(C)(C)C)NCCCCBr
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (396.59 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9659 mL 19.8295 mL 39.6589 mL
5 mM 0.7932 mL 3.9659 mL 7.9318 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (476 KB)

COA (242 KB) HNMR (118 KB) MS (267 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9659 mL 19.8295 mL 39.6589 mL 99.1473 mL
5 mM 0.7932 mL 3.9659 mL 7.9318 mL 19.8295 mL
10 mM 0.3966 mL 1.9829 mL 3.9659 mL 9.9147 mL
15 mM 0.2644 mL 1.3220 mL 2.6439 mL 6.6098 mL
20 mM 0.1983 mL 0.9915 mL 1.9829 mL 4.9574 mL
25 mM 0.1586 mL 0.7932 mL 1.5864 mL 3.9659 mL
30 mM 0.1322 mL 0.6610 mL 1.3220 mL 3.3049 mL
40 mM 0.0991 mL 0.4957 mL 0.9915 mL 2.4787 mL
50 mM 0.0793 mL 0.3966 mL 0.7932 mL 1.9829 mL
60 mM 0.0661 mL 0.3305 mL 0.6610 mL 1.6525 mL
80 mM 0.0496 mL 0.2479 mL 0.4957 mL 1.2393 mL
100 mM 0.0397 mL 0.1983 mL 0.3966 mL 0.9915 mL
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Boc-NH-C4-Br Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-NH-C4-Br164365-88-2PROTAC LinkersInhibitorinhibitorinhibit

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