2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. BPIQ-I

BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively.

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BPIQ-I Chemical Structure

BPIQ-I Chemical Structure

CAS No. : 174709-30-9

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Based on 1 publication(s) in Google Scholar

BPIQ-I Related Antibodies

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Description

BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively[1][2].

In Vitro

BPIQ-I (0-50 µM; 3 days) shows antiproliferative activity with EC50s of >50, 30, >50, 6.5, >50 µM for A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells, respectively[1].
BPIQ-I (10 nM) blocks erbB RTKs by competing with ATP, eliminating the CO2 sensitivity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BPIQ-I Related Antibodies

Cell Viability Assay [1]

Cell Line: A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells
Concentration: 0-50 µM
Incubation Time: 3 days
Result: Inhibited cells growth with EC50s of >50, 30, >50, 6.5, >50 µM for A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells, respectively.
Molecular Weight

354.20

Formula

C16H12BrN5
CAS No.
SMILES

CN1C=NC2=CC3=C(NC4=CC=CC(Br)=C4)N=CN=C3C=C21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BPIQ-I Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPIQ-I174709-30-9PD 159121PD159121PD-159121EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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