2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. HJC0416

HJC0416 is a potent and orally active STAT3 inhibitor. HJC0416 shows antiprolifeative activity and induces apoptosis. HJC0416 decreases the expression of p-STAT3 (Tyr-705), Cyclin D1 and increases the expression of cleaved caspase-3 protein. HJC0416 shows anti-tumor activity.

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HJC0416 Chemical Structure

HJC0416 Chemical Structure

CAS No. : 1617518-22-5

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HJC0416 Related Antibodies

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Description

HJC0416 is a potent and orally active STAT3 inhibitor. HJC0416 shows antiprolifeative activity and induces apoptosis. HJC0416 decreases the expression of p-STAT3 (Tyr-705), Cyclin D1 and increases the expression of cleaved caspase-3 protein. HJC0416 shows anti-tumor activity[1].

IC50 & Target[1]

STAT3

 

In Vitro

HJC0416 (0-10 µM; 48 h) shows antiprolifeative activity and induces apoptosis in MDA-MB-231 cells[1].
HJC0416 (0-10 µM; 12 h) decreases the expression of p-STAT3 (Tyr-705), Cyclin D1 and increases the expression of cleaved caspase-3 protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HJC0416 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-231, AsPC1, Panc-1 cells
Concentration: 0-100 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s 1.76, 1.97, 0.04, 1.88 µM for MCF-7, MDA-MB-231, AsPC1, Panc-1 cells, respectively.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1, 5, 10 µM
Incubation Time: 48 h
Result: Induced cell apoptosis.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0, 1, 5, 10 µM
Incubation Time: 12 h
Result: Suppressed the expression of phosphorylated STAT3 at Tyr-705, Cyclin D1, increased the expression of cleaved caspase-3.
In Vivo

HJC0416 (10 mg/kg for i.p.; 100 mg/kg for p.o.; daily for 7 days) reduces the tumor growth with no significant body weight loss in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 weeks, female nude mice (MDA-MB-231 cells)[1]
Dosage: 10 mg/kg for i.p.; 100 mg/kg for p.o.
Administration: I.p. or p.o.; daily for 7 days
Result: Decreased the tumor volume for 67% as compared to the control mice for i.p.; the growth of xenograft tumors in mice was also significantly reduced at a dose of 100 mg/kg by 46%.
Molecular Weight

392.86

Formula

C18H17ClN2O4S
CAS No.
SMILES

O=C(NC1=CC=C(C=CS2(=O)=O)C2=C1)C3=CC(Cl)=CC=C3OCCCN
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HJC0416 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HJC04161617518-22-5HJC 0416HJC-0416STATApoptosisantiprolifeativeantitumororally activeapoptosisMDA-MB-231 cellsp-STAT3 (Tyr-705)Cyclin D1cleaved caspase-3Inhibitorinhibitorinhibit

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