2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRD4-IN-4

BRD4-IN-4 (Compound 1) is a BRD4 inhibitor (IC50=6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia.

For research use only. We do not sell to patients.

BRD4-IN-4 Chemical Structure

BRD4-IN-4 Chemical Structure

CAS No. : 304685-40-3

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Based on 1 publication(s) in Google Scholar

BRD4-IN-4 Related Antibodies

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Description

BRD4-IN-4 (Compound 1) is a BRD4 inhibitor (IC50=6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia[1].

IC50 & Target

IC50: 6.83 μM (BRD4)[1]
Cellular Effect
Cell Line Type Value Description References
MV4-11 IC50
11.67 μM
Compound: 1
Antiproliferative activity against human MV4-11 cells after 72 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by CellTiter-Glo luminescent assay
[PMID: 29730189]
Molecular Weight

330.40

Formula

C17H18N2O3S
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1C2=CC=CC3=C(S(=O)(N4CCCC4)=O)C=CC(N1CC)=C32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (302.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0266 mL 15.1332 mL 30.2663 mL
5 mM 0.6053 mL 3.0266 mL 6.0533 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0266 mL 15.1332 mL 30.2663 mL 75.6659 mL
5 mM 0.6053 mL 3.0266 mL 6.0533 mL 15.1332 mL
10 mM 0.3027 mL 1.5133 mL 3.0266 mL 7.5666 mL
15 mM 0.2018 mL 1.0089 mL 2.0178 mL 5.0444 mL
20 mM 0.1513 mL 0.7567 mL 1.5133 mL 3.7833 mL
25 mM 0.1211 mL 0.6053 mL 1.2107 mL 3.0266 mL
30 mM 0.1009 mL 0.5044 mL 1.0089 mL 2.5222 mL
40 mM 0.0757 mL 0.3783 mL 0.7567 mL 1.8916 mL
50 mM 0.0605 mL 0.3027 mL 0.6053 mL 1.5133 mL
60 mM 0.0504 mL 0.2522 mL 0.5044 mL 1.2611 mL
80 mM 0.0378 mL 0.1892 mL 0.3783 mL 0.9458 mL
100 mM 0.0303 mL 0.1513 mL 0.3027 mL 0.7567 mL
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BRD4-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4-IN-4304685-40-3Epigenetic Reader DomainLeukemiaMLLMV4-11 cellInhibitorinhibitorinhibit

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HY-153751
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