2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. BuChE-IN-11

BuChE-IN-11 (Compound 3b-1) is an selective BuChE inhibitor with an IC50 of 0.44 μM for hBuChE. BuChE-IN-11 has high blood-brain barrier permeability and exhibits strong antioxidant activity due to its free radical scavenging properties. BuChE-IN-11 interacts with the choline binding site, acetyl binding site, and peripheral anionic site, exhibiting submicromolar BuChE inhibitory activity and preventing β-amyloid (Aβ) self-aggregation. BuChE-IN-11 holds promise for research in the field of Alzheimer's disease.

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BuChE-IN-11 Chemical Structure

BuChE-IN-11 Chemical Structure

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BuChE-IN-11 Related Antibodies

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Description

BuChE-IN-11 (Compound 3b-1) is an selective BuChE inhibitor with an IC50 of 0.44 μM for hBuChE. BuChE-IN-11 has high blood-brain barrier permeability and exhibits strong antioxidant activity due to its free radical scavenging properties. BuChE-IN-11 interacts with the choline binding site, acetyl binding site, and peripheral anionic site, exhibiting submicromolar BuChE inhibitory activity and preventing β-amyloid (Aβ) self-aggregation. BuChE-IN-11 holds promise for research in the field of Alzheimer's disease[1].

IC50 & Target[1]

hBCHE

0.44 μM (IC50)

eqBCHE

 

In Vitro

BuChE-IN-11 (Compound 3b-1) (0.1-1 µM, 120 min) demonstrates strong antioxidant activity[1].
BuChE-IN-11 (20 μM, 48h) inhibits the aggregation of αβ1-42[1].
BuChE-IN-11 (12.5-100 μM for PC12, 25-100 μM for AML12 over 24 hours) shows no significant toxicity to PC12 and AML12 cells at concentrations below 25 μM[1].
BuChE-IN-11 exhibits good blood-brain barrier permeability (CNS+) after 18 hours, indicating its ability to cross the blood-brain barrier[1].
BuChE-IN-11 is predicted to have high gastrointestinal absorption activity and low risk of cardiac toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BuChE-IN-11 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: PC12 and AML12 cells
Concentration: 12.5-100 μM for PC12, 25-100 μM for AML12
Incubation Time: 24 h
Result: Only exhibited significant cytotoxicity at concentrations greater than 25 µM. At concentrations below 25 µM, BuChE-IN-11 shows no significant cytotoxicity against PC12 and AML12 cells.
Molecular Weight

470.54

Formula

C28H27FN4O2
SMILES

O=C(NCCC1=CNC2=C1C=CC=C2)[C@@H](NCC3=CC=C(O)C(F)=C3)CC4=CNC5=C4C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BuChE-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BuChE-IN-11Cholinesterase (ChE)PC12 and AML12 cellsAntioxidant activityAlzheimer's diseaseInhibitorinhibitorinhibit

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