2. GPCR/G Protein Immunology/Inflammation
  3. CXCR Formyl Peptide Receptor (FPR)
  4. BVT173187

BVT173187 is a selective inhibitor of the neutrophil formyl peptide receptor FPR1, with activity that inhibits FPR1 activation. BVT173187 inhibits FPR1 agonist-induced activation in neutrophils, reduces adhesion molecule mobilization and superoxide anion production, and has inhibitory activity on FPR1 similar to that of earlier described peptide antagonists, but also has effects on C5aR and CXCR signaling.

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BVT173187 Chemical Structure

BVT173187 Chemical Structure

CAS No. : 1374984-75-4

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Based on 1 publication(s) in Google Scholar

BVT173187 Related Antibodies

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Description

BVT173187 is a selective inhibitor of the neutrophil formyl peptide receptor FPR1, with activity that inhibits FPR1 activation. BVT173187 inhibits FPR1 agonist-induced activation in neutrophils, reduces adhesion molecule mobilization and superoxide anion production, and has inhibitory activity on FPR1 similar to that of earlier described peptide antagonists, but also has effects on C5aR and CXCR signaling.

Molecular Weight

330.59

Formula

C14H10Cl3NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(Cl)=CC(Cl)=C1O)NC2=CC(C)=CC=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (302.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0249 mL 15.1245 mL 30.2489 mL
5 mM 0.6050 mL 3.0249 mL 6.0498 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0249 mL 15.1245 mL 30.2489 mL 75.6224 mL
5 mM 0.6050 mL 3.0249 mL 6.0498 mL 15.1245 mL
10 mM 0.3025 mL 1.5124 mL 3.0249 mL 7.5622 mL
15 mM 0.2017 mL 1.0083 mL 2.0166 mL 5.0415 mL
20 mM 0.1512 mL 0.7562 mL 1.5124 mL 3.7811 mL
25 mM 0.1210 mL 0.6050 mL 1.2100 mL 3.0249 mL
30 mM 0.1008 mL 0.5041 mL 1.0083 mL 2.5207 mL
40 mM 0.0756 mL 0.3781 mL 0.7562 mL 1.8906 mL
50 mM 0.0605 mL 0.3025 mL 0.6050 mL 1.5124 mL
60 mM 0.0504 mL 0.2521 mL 0.5041 mL 1.2604 mL
80 mM 0.0378 mL 0.1891 mL 0.3781 mL 0.9453 mL
100 mM 0.0302 mL 0.1512 mL 0.3025 mL 0.7562 mL
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BVT173187 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BVT1731871374984-75-4BVT 173187BVT-173187CXCRFormyl Peptide Receptor (FPR)CXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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