2. GPCR/G Protein Immunology/Inflammation
  3. CXCR Formyl Peptide Receptor (FPR)
  4. BVT173187

BVT173187 is a selective inhibitor of the neutrophil formyl peptide receptor FPR1, with activity that inhibits FPR1 activation. BVT173187 inhibits FPR1 agonist-induced activation in neutrophils, reduces adhesion molecule mobilization and superoxide anion production, and has inhibitory activity on FPR1 similar to that of earlier described peptide antagonists, but also has effects on C5aR and CXCR signaling.

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BVT173187 Chemical Structure

BVT173187 Chemical Structure

CAS No. : 1374984-75-4

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BVT173187 Related Antibodies

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Description

BVT173187 is a selective inhibitor of the neutrophil formyl peptide receptor FPR1, with activity that inhibits FPR1 activation. BVT173187 inhibits FPR1 agonist-induced activation in neutrophils, reduces adhesion molecule mobilization and superoxide anion production, and has inhibitory activity on FPR1 similar to that of earlier described peptide antagonists, but also has effects on C5aR and CXCR signaling.

Molecular Weight

330.59

Formula

C14H10Cl3NO2
CAS No.
SMILES

O=C(C1=CC(Cl)=CC(Cl)=C1O)NC2=CC(C)=CC=C2Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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BVT173187 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BVT1731871374984-75-4BVT 173187BVT-173187CXCRFormyl Peptide Receptor (FPR)CXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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