2. PROTAC
  3. Ligands for E3 Ligase
  4. BWA-522 intermediate-1

BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7.

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BWA-522 intermediate-1 Chemical Structure

BWA-522 intermediate-1 Chemical Structure

CAS No. : 2241315-66-0

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BWA-522 intermediate-1 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7[1].

Molecular Weight

369.37

Formula

C19H19N3O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=CC1CCN(C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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BWA-522 intermediate-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BWA-522 intermediate-12241315-66-0Ligands for E3 LigaseE3 ligase-recruiting MoietyPROTACligand for E3 ubiquitin ligaseAR-FLAR-V7Inhibitorinhibitorinhibit

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