C5aR2 agonist P32

Cat. No.: HY-P10639 Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

C5aR2 agonist P32 (Ac-RHYPYWR-OH) is a C5aR2-selective agonist. C5aR2 agonist P32 has been shown to elicit multiple immunomodulatory activities, both by down-regulating the C5aR1-mediated cell signalling, and acting in a C5aR1-independent fashion, in vitro and in vivo.

For research use only. We do not sell to patients.

C5aR2 agonist P32 Chemical Structure

CAS No. : 2097449-46-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of C5aR2 agonist P32:

C5aR2 agonist P32 acetate Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Complement C5a receptor 2 (C5aR2)^[1]

Molecular Weight

1119.23

Formula

C₅₄H₇₀N₁₆O₁₁

CAS No.

2097449-46-0

Appearance

Solid

Color

White to off-white

Sequence

Ac-Arg-His-Tyr-Pro-Tyr-Trp-Arg

Sequence Shortening

Ac-RHYPYWR

SMILES

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=C(C=C2)O)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (89.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8935 mL	4.4674 mL	8.9347 mL
5 mM	0.1787 mL	0.8935 mL	1.7869 mL
10 mM	0.0893 mL	0.4467 mL	0.8935 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (262 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Li XX, et al. Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonists. Int Immunopharmacol. 2021 Nov;100:108074. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8935 mL	4.4674 mL	8.9347 mL	22.3368 mL
	5 mM	0.1787 mL	0.8935 mL	1.7869 mL	4.4674 mL
	10 mM	0.0893 mL	0.4467 mL	0.8935 mL	2.2337 mL
	15 mM	0.0596 mL	0.2978 mL	0.5956 mL	1.4891 mL
	20 mM	0.0447 mL	0.2234 mL	0.4467 mL	1.1168 mL
	25 mM	0.0357 mL	0.1787 mL	0.3574 mL	0.8935 mL
	30 mM	0.0298 mL	0.1489 mL	0.2978 mL	0.7446 mL
	40 mM	0.0223 mL	0.1117 mL	0.2234 mL	0.5584 mL
	50 mM	0.0179 mL	0.0893 mL	0.1787 mL	0.4467 mL
	60 mM	0.0149 mL	0.0745 mL	0.1489 mL	0.3723 mL
	80 mM	0.0112 mL	0.0558 mL	0.1117 mL	0.2792 mL