2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. CA/MAO-B-IN-1

CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction.

For research use only. We do not sell to patients.

CA/MAO-B-IN-1 Chemical Structure

CA/MAO-B-IN-1 Chemical Structure

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Based on 1 publication(s) in Google Scholar

CA/MAO-B-IN-1 Related Antibodies

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Description

CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction[1].

IC50 & Target

hCA VB

8.8 nM (IC50)

hCA VA

9.6 nM (IC50)

hCA II

41.1 nM (IC50)

hCA XII

196 nM (IC50)

hCA I

553.1 nM (IC50)

In Vitro

CA/MAO-B-IN-1 (12.5-50 μM) reverts formation of ROS, exhibits neuro- and mitochondrial protective effects against Aβ1-42 oligomer-induced neurotoxicity in cells SH-SY5Y[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CA/MAO-B-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y
Concentration: 12.5-50 μM
Incubation Time: 24 h
Result: Improved cell viability in SH-SY5Y cells damaged by Aβ1-42.
Molecular Weight

345.37

Formula

C17H15NO5S
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(COC2=CC(O3)=C(C=C2)C=C(C)C3=O)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (506.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8954 mL 14.4772 mL 28.9545 mL
5 mM 0.5791 mL 2.8954 mL 5.7909 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8954 mL 14.4772 mL 28.9545 mL 72.3861 mL
5 mM 0.5791 mL 2.8954 mL 5.7909 mL 14.4772 mL
10 mM 0.2895 mL 1.4477 mL 2.8954 mL 7.2386 mL
15 mM 0.1930 mL 0.9651 mL 1.9303 mL 4.8257 mL
20 mM 0.1448 mL 0.7239 mL 1.4477 mL 3.6193 mL
25 mM 0.1158 mL 0.5791 mL 1.1582 mL 2.8954 mL
30 mM 0.0965 mL 0.4826 mL 0.9651 mL 2.4129 mL
40 mM 0.0724 mL 0.3619 mL 0.7239 mL 1.8097 mL
50 mM 0.0579 mL 0.2895 mL 0.5791 mL 1.4477 mL
60 mM 0.0483 mL 0.2413 mL 0.4826 mL 1.2064 mL
80 mM 0.0362 mL 0.1810 mL 0.3619 mL 0.9048 mL
100 mM 0.0290 mL 0.1448 mL 0.2895 mL 0.7239 mL
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CA/MAO-B-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CA/MAO-B-IN-1Carbonic AnhydraseCarbonate dehydrataseSH-SY5YAβ1-42Alzheimer’s diseaseInhibitorinhibitorinhibit

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