2. Others Cell Cycle/DNA Damage Cytoskeleton Autophagy
  3. Isotope-Labeled Compounds Microtubule/Tubulin Autophagy
  4. Cabazitaxel-d9

Cabazitaxel-d9  (Synonyms: XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9)

Cat. No.: HY-15459S1 Purity: 99.4%
COA Handling Instructions

Molarity Calculator

Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

For research use only. We do not sell to patients.

Cabazitaxel-d<sub>9</sub> Chemical Structure

Cabazitaxel-d9 Chemical Structure

CAS No. : 1383572-19-7

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1 mg USD 770 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cabazitaxel-d9:

Cabazitaxel-d9 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cabazitaxel-d9 Related Antibodies
Molecular Weight

844.99

Formula

C45H48D9NO14
CAS No.
Unlabeled CAS

183133-96-2
Appearance

Solid

Color

White to off-white

SMILES

CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)OC)C)=O)OC)=C([C@H](C4)OC([C@H](O)[C@H](C5=CC=CC=C5)NC(OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=O)C)C)O)OC(C6=CC=CC=C6)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (118.34 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1834 mL 5.9172 mL 11.8345 mL
5 mM 0.2367 mL 1.1834 mL 2.3669 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.4%

COA (262 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1834 mL 5.9172 mL 11.8345 mL 29.5861 mL
5 mM 0.2367 mL 1.1834 mL 2.3669 mL 5.9172 mL
10 mM 0.1183 mL 0.5917 mL 1.1834 mL 2.9586 mL
15 mM 0.0789 mL 0.3945 mL 0.7890 mL 1.9724 mL
20 mM 0.0592 mL 0.2959 mL 0.5917 mL 1.4793 mL
25 mM 0.0473 mL 0.2367 mL 0.4734 mL 1.1834 mL
30 mM 0.0394 mL 0.1972 mL 0.3945 mL 0.9862 mL
40 mM 0.0296 mL 0.1479 mL 0.2959 mL 0.7397 mL
50 mM 0.0237 mL 0.1183 mL 0.2367 mL 0.5917 mL
60 mM 0.0197 mL 0.0986 mL 0.1972 mL 0.4931 mL
80 mM 0.0148 mL 0.0740 mL 0.1479 mL 0.3698 mL
100 mM 0.0118 mL 0.0592 mL 0.1183 mL 0.2959 mL
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Cabazitaxel-d9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cabazitaxel-d91383572-19-7XRP6258-d9RPR-116258A-d9taxoid XRP6258-d9Isotope-Labeled CompoundsMicrotubule/TubulinAutophagyInhibitorinhibitorinhibit

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