Calcineurin autoinhibitory peptide

Name: Calcineurin autoinhibitory peptide
Brand: MedChemExpress
SKU: HY-P1247
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1247 Purity: 99.96%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Calcineurin autoinhibitory peptide is a selective inhibitor of Ca²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Calcineurin autoinhibitory peptide Chemical Structure

CAS No. : 148067-21-4

Size	Price	Stock	Quantity
1 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 760	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Calcineurin autoinhibitory peptide:

Calcineurin autoinhibitory peptide TFA Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: ~10 μM (calcineurin)^[1]

Molecular Weight

2930.32

Formula

C₁₂₄H₂₀₅N₃₉O₃₉S₂

CAS No.

148067-21-4

Appearance

Solid

Color

White to off-white

Sequence Shortening

ITSFEEAKGLDRINERMPPRRDAMP

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (34.13 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3413 mL	1.7063 mL	3.4126 mL
5 mM	0.0683 mL	0.3413 mL	0.6825 mL
10 mM	0.0341 mL	0.1706 mL	0.3413 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (34.13 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (242 KB) LCMS (90 KB) Elemental Analysis Report (100 KB)

Handling Instructions (2659 KB)

References

[1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7. [Content Brief]

[2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.3413 mL	1.7063 mL	3.4126 mL	8.5315 mL
	5 mM	0.0683 mL	0.3413 mL	0.6825 mL	1.7063 mL
	10 mM	0.0341 mL	0.1706 mL	0.3413 mL	0.8531 mL
	15 mM	0.0228 mL	0.1138 mL	0.2275 mL	0.5688 mL
	20 mM	0.0171 mL	0.0853 mL	0.1706 mL	0.4266 mL
	25 mM	0.0137 mL	0.0683 mL	0.1365 mL	0.3413 mL
	30 mM	0.0114 mL	0.0569 mL	0.1138 mL	0.2844 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.