2. Peptides
  3. Peptide and Derivatives
  4. Peptides for Drug Delivery
  5. Cell-penetrating Peptides
  6. 134-05-4

134-05-4

10-Formylfolic acid Chemical Structure

134-05-4

Chemical Structure

  • 10-Formylfolic acid
  • CAS No: 134-05-4
    Formula: C20H19N7O7
    Molecular Weight: 469.41
  • IUPAC Name: (4-(N-((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzoyl)-L-glutamic acid
  • InChIKey: UGWUWNVTCLDEOG-ZDUSSCGKSA-N
  • SMILES: O=C(O)[C@@H](NC(C1=CC=C(N(C=O)CC2=NC3=C(N=C2)N=C(N)NC3=O)C=C1)=O)CCC(O)=O

Biological Activity: 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].

References

[1]. M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9. [Content Brief]
[2]. J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8. [Content Brief]

Keywords:

10-Formylfolic acid10-Formylfolic acid (Standard)10-Formylfolic acid-d4