2. GPCR/G Protein
  3. P2Y Receptor
  4. 2982696-04-6

2982696-04-6

PPARδ agonist 11 Chemical Structure

2982696-04-6

Chemical Structure

  • PPARδ agonist 11
  • CAS No: 2982696-04-6
    Formula: C19H15F3N2O3S2
    Molecular Weight: 440.46
  • InChIKey: NLJZRFBMZSIDNW-UHFFFAOYSA-N
  • SMILES: CC1=CC(SCC(S2)=NN=C2C3=CC=C(C(F)(F)F)C=C3)=CC=C1OCC(O)=O

Biological Activity: PPARδ agonist 11 (Compound 11) is a selective agonist for PPARδ with an EC50 of 20 nM. PPARδ agonist 11 reduces the levels of nitrite oxide (NO), proinflammatory cytokines TNFα and IL-6 in LPS (HY-D1056)-stimulated RAW264.7 cell, and exhibits anti-inflammatory efficacy via NF-κB pathway. PPARδ agonist 11 exhibits good stability in human liver microsomes and plasma. PPARδ agonist 11 ameliorates Carrageenan (HY-125474)-induced foot edema[1].

Cat. No. Product Name Purity Description
HY-162963 PPARδ agonist 11 PPARδ agonist 11 (Compound 11) is a selective agonist for PPARδ with an EC50 of 20 nM. PPARδ agonist 11 reduces the levels of nitrite oxide (NO), proinflammatory cytokines TNFα and IL-6 in LPS (HY-D1056)-stimulated RAW264.7 cell, and exhibits anti-inflammatory efficacy via NF-κB pathway. PPARδ agonist 11 exhibits good stability in human liver microsomes and plasma. PPARδ agonist 11 ameliorates Carrageenan (HY-125474)-induced foot edema.

References

[1]. Kim J, et al., Discovery of the therapeutic potential of PPARδ agonist bearing 1,3,4- thiadiazole in inflammatory disorders. Eur J Med Chem. 2024 Sep 12;279:116856. [Content Brief]

Keywords:

PPARδ agonist 11