2. Others Anti-infection
  3. Biochemical Assay Reagents Bacterial
  4. 2089334-95-0

2089334-95-0

BMS-202 hydrochloride Chemical Structure

2089334-95-0

Chemical Structure

  • BMS-202 hydrochloride
  • CAS No: 2089334-95-0
    Formula: C25H30ClN3O3
    Molecular Weight: 455.98
  • IUPAC Name: N-(2-(((2-methoxy-6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)pyridin-3-yl)methyl)amino)ethyl)acetamide hydrochloride
  • InChIKey: XGIQBUNWFCCMAS-UHFFFAOYSA-N
  • SMILES: CC(NCCNCC1=CC=C(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)N=C1OC)=O.[H]Cl

Biological Activity: BMS-202 hydrochloride is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 hydrochloride binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 hydrochloride has antitumor activity[1][2].

Cat. No. Product Name Purity Description
HY-19745B BMS-202 hydrochloride BMS-202 hydrochloride is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 hydrochloride binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 hydrochloride has antitumor activity.

References

[1]. Zak KM, et al. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1). Oncotarget. 2016 May 24;7(21):30323-35. [Content Brief]
[2]. Ashizawa T, et al. Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse. Biomed Res. 2019;40(6):243-250. [Content Brief]

Keywords:

BMS-202 hydrochloride