2. 1481636-41-2

1481636-41-2

5-PAHSA Chemical Structure

1481636-41-2

Chemical Structure

  • 5-PAHSA
  • CAS No: 1481636-41-2
    Formula: C34H66O4
    Molecular Weight: 538.89
  • IUPAC Name: 5-(palmitoyloxy)octadecanoic acid
  • InChIKey: QBGKCWKQYJQHJX-UHFFFAOYSA-N
  • SMILES: OC(CCCC(CCCCCCCCCCCCC)OC(CCCCCCCCCCCCCCC)=O)=O

Biological Activity: 5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics[1][2][3].

Cat. No. Product Name Purity Description
HY-116193 5-PAHSA 98.08% 5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics.
HY-144024S 5-PAHSA-d9 5-PAHSA-d9 is the deuterium labeled 5-PAHSA (HY-116193). 5-PAHSA is a kind of anti-inflammatory and antidiabetic lipokines that connect glucose and lipid metabolism.
HY-116193S 5-PAHSA-d31 5-PAHSA-d31 is the deuterium labeled 5-PAHSA.

References

[1]. Wang JT, et al. A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy. CNS Neurosci Ther. 2021 Apr;27(4):484-496. [Content Brief]
[2]. Paluchova V, et al. Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice. Diabetes. 2020 Mar;69(3):300-312. [Content Brief]
[3]. Wang YM, et al. High Glucose Concentration Impairs 5-PAHSA Activity by Inhibiting AMP-Activated Protein Kinase Activation and Promoting Nuclear Factor-Kappa-B-Mediated Inflammation. Front Pharmacol. 2019 Jan 7;9:1491. [Content Brief]

Keywords:

5-PAHSA5-PAHSA-d95-PAHSA-d31