2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 5-PAHSA

5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics.

For research use only. We do not sell to patients.

5-PAHSA Chemical Structure

5-PAHSA Chemical Structure

CAS No. : 1481636-41-2

Size Price Stock Quantity
1 mg USD 100 In-stock
5 mg USD 200 In-stock
10 mg USD 360 In-stock
25 mg USD 720 In-stock
50 mg USD 1150 In-stock
100 mg USD 1840 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 5-PAHSA:

5-PAHSA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics[1][2][3].

In Vitro

5-PAHSA (30 μM, 12 h) reduces the levels of ROS and induces autophagy in PC12 cells[1].
5-PAHSA (20 μM, 2 days) reduces high insulin- and TNF-α-induced insulin resistance in HepG2 cells and 3T3-L1 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-PAHSA Related Antibodies
In Vivo

5-PAHSA (50 and 150 mg/kg, oral gavage, 30 days) inhibits lipid peroxidation in DB/DB mice[1].
5-PAHSA (45 mg/kg, oral gavage, 3 days) stimulates De novo lipogenesis and lipid remodeling in epididymal WAT (eWAT) during cold exposure in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

538.89

Formula

C34H66O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CCCC(CCCCCCCCCCCCC)OC(CCCCCCCCCCCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (30.93 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8557 mL 9.2783 mL 18.5567 mL
5 mM 0.3711 mL 1.8557 mL 3.7113 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 1.67 mg/mL (3.10 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 1.67 mg/mL.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 1.67 mg/mL (3.10 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 1.67 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8557 mL 9.2783 mL 18.5567 mL 46.3917 mL
5 mM 0.3711 mL 1.8557 mL 3.7113 mL 9.2783 mL
10 mM 0.1856 mL 0.9278 mL 1.8557 mL 4.6392 mL
15 mM 0.1237 mL 0.6186 mL 1.2371 mL 3.0928 mL
20 mM 0.0928 mL 0.4639 mL 0.9278 mL 2.3196 mL
25 mM 0.0742 mL 0.3711 mL 0.7423 mL 1.8557 mL
30 mM 0.0619 mL 0.3093 mL 0.6186 mL 1.5464 mL
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5-PAHSA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-PAHSA1481636-41-2Endogenous Metaboliteinsulinanti-inflammatoryHFDdiabetesneurological dysfunctionInhibitorinhibitorinhibit

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