Cathepsin L/S-IN-1

Cat. No.: HY-152204: FAQs
Data Sheet Handling Instructions

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Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC₅₀s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells.

For research use only. We do not sell to patients.

Cathepsin L/S-IN-1 Chemical Structure

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

cathepsin L

4.10 μM (IC₅₀)

cathepsin S

1.79 μM (IC₅₀)

In Vitro

Cathepsin L/S-IN-1 (compound B1a) (0-25 μM; 48 h) shows noncytotoxic agaisnt pancreatic cancer BxPC-3 and PANC-1 cells^[1].
Cathepsin L/S-IN-1 (0-25 μM; 48 h) inhibits Cathepsin L and S activities without decreasing the mRNA level of them^[1].
Cathepsin L/S-IN-1 (0-25 μM; 48 h) inhibits the migration and invasion of pancreatic cancer BxPC-3 and PANC-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	BxPC-3 and PANC-1 cells
Concentration:	0, 6.25, 12.5, and 25 μM
Incubation Time:	48 hours
Result:	Failed to suppress the viability of pancreatic cancer cells.

Molecular Weight

613.57

Formula

C₂₉H₃₃BrN₄O₄S

SMILES

O[C@@H](COC[C@H](NS(=O)(C1=CC=C(C=C1)Br)=O)CC2=CC=CC=C2)CN(CC3)CCN3C(C=CC=C4)=C4C#N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang H, et al. Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells. Bioorg Med Chem Lett. 2022 Nov 23;80:129087. [Content Brief]

Cathepsin L/S-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cathepsin L/S-IN-1CathepsinInhibitorinhibitorinhibit

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