CB7993113 

CB7993113 is a potent AHR antagonist, with an IC₅₀ of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively^[1].

CB7993113 exhibits no toxicity when added at concentrations at least up to 20 μM to several human cells including HepG2 hepatoma cells, BP1, D3, Hs578T, or MDA-MB-231 breast cancer cells, and primary human-induced pluripotent stem cells^[1].
CB7993113 significantly reduces the invasive phenotype of ER-/PR-/HER2- breast cancer cells in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB7993113 effectively blocks acute, 50 mg/kg DMBA-induced hepatic CYP1A1 induction and bone marrow toxicity in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

364.15

C₁₅H₁₀BrNO₅

819827-50-4

Solid

White to yellow

O=C(N)COC1=C(C2=CC=C(Br)O2)OC3=CC=CC=C3C1=O

Room temperature in continental US; may vary elsewhere.

• [1]. Parks AJ, et al. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol. 2014 Nov;86(5):593-608.  [Content Brief]