2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. CB7993113

CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively.

For research use only. We do not sell to patients.

CB7993113 Chemical Structure

CB7993113 Chemical Structure

CAS No. : 819827-50-4

Size Price Stock Quantity
5 mg USD 140 In-stock
10 mg USD 230 In-stock
25 mg USD 468 In-stock
50 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

CB7993113 Related Antibodies

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Description

CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively[1].

In Vitro

CB7993113 exhibits no toxicity when added at concentrations at least up to 20 μM to several human cells including HepG2 hepatoma cells, BP1, D3, Hs578T, or MDA-MB-231 breast cancer cells, and primary human-induced pluripotent stem cells[1].
CB7993113 significantly reduces the invasive phenotype of ER-/PR-/HER2- breast cancer cells in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB7993113 Related Antibodies
In Vivo

CB7993113 effectively blocks acute, 50 mg/kg DMBA-induced hepatic CYP1A1 induction and bone marrow toxicity in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

364.15

Formula

C15H10BrNO5
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(N)COC1=C(C2=CC=C(Br)O2)OC3=CC=CC=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (137.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7461 mL 13.7306 mL 27.4612 mL
5 mM 0.5492 mL 2.7461 mL 5.4922 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7461 mL 13.7306 mL 27.4612 mL 68.6530 mL
5 mM 0.5492 mL 2.7461 mL 5.4922 mL 13.7306 mL
10 mM 0.2746 mL 1.3731 mL 2.7461 mL 6.8653 mL
15 mM 0.1831 mL 0.9154 mL 1.8307 mL 4.5769 mL
20 mM 0.1373 mL 0.6865 mL 1.3731 mL 3.4327 mL
25 mM 0.1098 mL 0.5492 mL 1.0984 mL 2.7461 mL
30 mM 0.0915 mL 0.4577 mL 0.9154 mL 2.2884 mL
40 mM 0.0687 mL 0.3433 mL 0.6865 mL 1.7163 mL
50 mM 0.0549 mL 0.2746 mL 0.5492 mL 1.3731 mL
60 mM 0.0458 mL 0.2288 mL 0.4577 mL 1.1442 mL
80 mM 0.0343 mL 0.1716 mL 0.3433 mL 0.8582 mL
100 mM 0.0275 mL 0.1373 mL 0.2746 mL 0.6865 mL
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CB7993113 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB7993113819827-50-4CB 7993113CB-7993113Aryl Hydrocarbon ReceptorAhRInhibitorinhibitorinhibit

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