2. PROTAC Apoptosis
  3. Molecular Glues Bcl-2 Family
  4. CCT373566

CCT373566 is a potent and orally active molecular glue degrader of transcriptional repressor BCL6, with an IC50 of 2.2 nM. CCT373566 shows strong antiproliferative efficacy in vitro and reduction in tumor growth in vivo.

For research use only. We do not sell to patients.

CCT373566 Chemical Structure

CCT373566 Chemical Structure

CAS No. : 2378853-66-6

Size Price Stock Quantity
1 mg USD 220 In-stock
5 mg USD 550 In-stock
10 mg USD 950 In-stock
25 mg USD 1900 In-stock
50 mg USD 2900 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

CCT373566 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CCT373566 is a potent and orally active molecular glue degrader of transcriptional repressor BCL6, with an IC50 of 2.2 nM. CCT373566 shows strong antiproliferative efficacy in vitro and reduction in tumor growth in vivo[1].

Cellular Effect
Cell Line Type Value Description References
HT GI50
8 nM
Compound: 12a; CCT373566
Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
KARPAS-422 GI50
1.4 nM
Compound: 12a; CCT373566
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
OCI-Ly1 GI50
2.1 nM
Compound: 12a; CCT373566
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
OCI-Ly3 GI50
1900 nM
Compound: 12a; CCT373566
Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
SUD4 GI50
12.5 nM
Compound: 12a; CCT373566
Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay
[PMID: 35653645]
Molecular Weight

547.00

Formula

C26H29ClF2N6O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C)C2=C(C=C(NC3=NC(N4C[C@H](O)C[C@H](C)C4)=NC=C3Cl)C=C2)C5=C1OCC(F)(F)[C@H](C6CC6)N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (91.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8282 mL 9.1408 mL 18.2815 mL
5 mM 0.3656 mL 1.8282 mL 3.6563 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8282 mL 9.1408 mL 18.2815 mL 45.7038 mL
5 mM 0.3656 mL 1.8282 mL 3.6563 mL 9.1408 mL
10 mM 0.1828 mL 0.9141 mL 1.8282 mL 4.5704 mL
15 mM 0.1219 mL 0.6094 mL 1.2188 mL 3.0469 mL
20 mM 0.0914 mL 0.4570 mL 0.9141 mL 2.2852 mL
25 mM 0.0731 mL 0.3656 mL 0.7313 mL 1.8282 mL
30 mM 0.0609 mL 0.3047 mL 0.6094 mL 1.5235 mL
40 mM 0.0457 mL 0.2285 mL 0.4570 mL 1.1426 mL
50 mM 0.0366 mL 0.1828 mL 0.3656 mL 0.9141 mL
60 mM 0.0305 mL 0.1523 mL 0.3047 mL 0.7617 mL
80 mM 0.0229 mL 0.1143 mL 0.2285 mL 0.5713 mL
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CCT373566 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT3735662378853-66-6CCT 373566CCT-373566Molecular GluesBcl-2 Familytranscriptional repressorBCL6antiproliferative efficacytumorInhibitorinhibitorinhibit

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