2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK Apoptosis
  3. CDK VEGFR PDGFR Apoptosis
  4. CDK2/FLT4/PDGFRA-IN-1

CDK2/FLT4/PDGFRA-IN-1 (Compound 4a) is a potent inhibitor of CDK2/cyclin A, FLT4 (VEGFR3) and PDGFRA, with IC50s of 1.672, 0.554, and 0.629 μM, respectively. CDK2/FLT4/PDGFRA-IN-1 exhibits potent antiproliferative effects against cancer cells. CDK2/FLT4/PDGFRA-IN-1 can also induce apoptosis in cancer cells.

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CDK2/FLT4/PDGFRA-IN-1 Chemical Structure

CDK2/FLT4/PDGFRA-IN-1 Chemical Structure

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CDK2/FLT4/PDGFRA-IN-1 Related Antibodies

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Description

CDK2/FLT4/PDGFRA-IN-1 (Compound 4a) is a potent inhibitor of CDK2/cyclin A, FLT4 (VEGFR3) and PDGFRA, with IC50s of 1.672, 0.554, and 0.629 μM, respectively. CDK2/FLT4/PDGFRA-IN-1 exhibits potent antiproliferative effects against cancer cells. CDK2/FLT4/PDGFRA-IN-1 can also induce apoptosis in cancer cells[1].

Molecular Weight

436.46

Formula

C26H20N4O3
SMILES

O=C1C(NC2=CC=C(OCC3=CN(CC4=CC=CC=C4)N=N3)C=C2)=CC(C5=C1C=CC=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK2/FLT4/PDGFRA-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2/FLT4/PDGFRA-IN-1CDKVEGFRPDGFRApoptosisCyclin dependent kinaseVascular endothelial growth factor receptorPlatelet-derived growth factor receptorInhibitorinhibitorinhibit

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