2. Cell Cycle/DNA Damage JAK/STAT Signaling
  3. CDK Pim
  4. CDK2/PIM1-IN-1

CDK2/PIM1-IN-1 is an inhibitor of CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM) kinases. CDK2/PIM1-IN-1 induces apoptosis and reduces tumor-promoting TNF-α expression. CDK2/PIM1-IN-1 has antitumor activity.

For research use only. We do not sell to patients.

CDK2/PIM1-IN-1 Chemical Structure

CDK2/PIM1-IN-1 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CDK2/PIM1-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

View All Pim Isoform Specific Products:

View All Isoforms
PIM1 PIM2 PIM3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CDK2/PIM1-IN-1 is an inhibitor of CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM) kinases. CDK2/PIM1-IN-1 induces apoptosis and reduces tumor-promoting TNF-α expression. CDK2/PIM1-IN-1 has antitumor activity[1].

IC50 & Target[1]

CDK2

0.27 μM (IC50)

PIM1

0.67 μM (IC50)

In Vitro

CDK2/PIM1-IN-1 (Compound 6b) (24 h) shows antiproliferative effects on MCF7 cells (IC50: 5.54 μM), HCT-116 cells (IC50: 2.62 μM), HepG2 cells (IC50: 3.99 μM) and HeLa cell lines (IC50: 8.31 μM), with moderate safety in the normal breast cell line MCF-10A (IC50: 39.44 μM) [1].
CDK2/PIM1-IN-1 (24 h) inhibits HCT116 cell line at the G0-G1 phase (%G0-G1: 83.43%) and induced significant early (8.28%) and late (20.09%) cell apoptosis[1].
CDK2/PIM1-IN-1 (24 h) shows inhibitory effects on both CDK (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM) in HCT116 cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2/PIM1-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: Tumor cell line (MCF7 cells, HCT-116 cells, HepG2 cells, HeLa cell lines), and the normal breast cell line MCF-10A.
Concentration:
Incubation Time: 24 h
Result: Inhibited the cell viability of MCF7 cells (IC50: 5.54 μM), HCT-116 cells (IC50: 2.62 μM), HepG2 cells (IC50: 3.99 μM) and HeLa cell lines (IC50: 8.31 μM).
Showed moderate safety in the normal breast cell line MCF-10A (IC50: 39.44 μM).
In Vivo

CDK2/PIM1-IN-1 (Compound 6b) (10 mg/kg; IP; three times weekly for two weeks) reduces tumor volume (71.42%) and weight (70.58%) in the solid Ehrlich carcinoma (SEC) mouse model and was well tolerated. [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Solid Ehrlich carcinoma (SEC) mouse model[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), three times weekly for two weeks.
Result: Reduced tumor volume (71.42%) and weight (70.58%).
Showed good tolerability (indicated by stable body weight and 100% survival rate compared with the Dox-treated group).
Inhibited CDK2 (70.96%) and PIM1 (53.61%) levels in mouse tumors, tumor cell mitosis (27.35%).
Inhibited tumor TNF-α expression (17.61%).
Molecular Weight

421.49

Formula

C27H23N3O2
SMILES

COC1=CC=C(C2=CC=NC3=C2C(C4=CC=C(C)C=C4)=NN3C5=CC=CC=C5)C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CDK2/PIM1-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2/PIM1-IN-1CDKPimCyclin dependent kinasePim kinasesAnti-cancerTNF-αsolid Ehrlich carcinoma (SEC)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CDK2/PIM1-IN-1
Cat. No.:
HY-173224
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.