2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK4/6-IN-20

CDK4/6-IN-20 (Compound II-5) is a CDK4/CDK6 inhibitor with IC50 values ​​of 1.9, 14.2 nM, respectively. CDK4/6-IN-20 also inhibits cell proliferation and can be used in cancer research.

For research use only. We do not sell to patients.

CDK4/6-IN-20 Chemical Structure

CDK4/6-IN-20 Chemical Structure

CAS No. : 3033950-84-1

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Description

CDK4/6-IN-20 (Compound II-5) is a CDK4/CDK6 inhibitor with IC50 values ​​of 1.9, 14.2 nM, respectively. CDK4/6-IN-20 also inhibits cell proliferation and can be used in cancer research[1].

IC50 & Target

CDK4

1.9 nM (IC50)

CDK6

14.2 nM (IC50)

In Vitro

CDK4/6-IN-20 inhibits the proliferation of MCF7 and T47D cells with IC50 values ​​of 169 and 92 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

421.47

Formula

C23H24FN5O2
CAS No.
SMILES

O[C@@H]1COCC[C@H]1NC2=NC=C(C#N)C(C3=CC(C4(CCCC4)C(C)=N5)=C5C(F)=C3)=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK4/6-IN-20 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CDK4/6-IN-203033950-84-1CDKCyclin dependent kinase2-aminopyrimidine compoundcell proliferationMCF7 cellsT47D cellsInhibitorinhibitorinhibit

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