Celecoxib-d₇ (Synonyms: SC 58635-d₇)

Name: Celecoxib-d 7
Brand: MedChemExpress
SKU: HY-14398S
Rating: 4.5 (1 reviews)

Cat. No.: HY-14398S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

For research use only. We do not sell to patients.

Celecoxib-d<sub>7</sub> Chemical Structure

Celecoxib-d₇ Chemical Structure

CAS No. : 544686-21-7

Size	Price	Stock	Quantity
500 μg	USD 210	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Celecoxib-d₇:

Celecoxib In-stock

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COX COX-1 COX-2 COX-3

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Purity & Documentation
References
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Description

Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

388.42

Formula

C₁₇H₇D₇F₃N₃O₂S

CAS No.

544686-21-7

Unlabeled CAS

169590-42-5

Appearance

Solid

Color

Off-white to gray

SMILES

NS(C1=CC=C(C=C1)N2C(C3=C(C([2H])=C(C([2H])=C3[2H])C([2H])([2H])[2H])[2H])=CC(C(F)(F)F)=N2)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 76 mg/mL (195.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 33 mg/mL (84.96 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5745 mL	12.8727 mL	25.7453 mL
5 mM	0.5149 mL	2.5745 mL	5.1491 mL
10 mM	0.2575 mL	1.2873 mL	2.5745 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (281 KB) SDS (252 KB)

COA (261 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Penning TD, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J Med Chem. 1997 [Content Brief]

[3]. Liu DB, et al. Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation. Acta Pharmacol Sin. 2012 May;33(5):682-90. [Content Brief]

[4]. Suri A, et al. The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer. Oncotarget. 2016 Apr 8. [Content Brief]

[5]. Hou XL, et al. Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone. Neural Regen Res. 2015 Nov;10(11):1836-40. [Content Brief]

[6]. Liu C, et al. Celecoxib alleviates nonalcoholic fatty liver disease by restoring autophagic flux. Sci Rep. 2018 Mar 7;8(1):4108. [Content Brief]

[7]. Pobbati AV, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10(8):3622-3635. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / Ethanol / DMSO / DMSO	1 mM	2.5745 mL	12.8727 mL	25.7453 mL	64.3633 mL
	5 mM	0.5149 mL	2.5745 mL	5.1491 mL	12.8727 mL
	10 mM	0.2575 mL	1.2873 mL	2.5745 mL	6.4363 mL
	15 mM	0.1716 mL	0.8582 mL	1.7164 mL	4.2909 mL
	20 mM	0.1287 mL	0.6436 mL	1.2873 mL	3.2182 mL
	25 mM	0.1030 mL	0.5149 mL	1.0298 mL	2.5745 mL
	30 mM	0.0858 mL	0.4291 mL	0.8582 mL	2.1454 mL
	40 mM	0.0644 mL	0.3218 mL	0.6436 mL	1.6091 mL
	50 mM	0.0515 mL	0.2575 mL	0.5149 mL	1.2873 mL
	60 mM	0.0429 mL	0.2145 mL	0.4291 mL	1.0727 mL
	80 mM	0.0322 mL	0.1609 mL	0.3218 mL	0.8045 mL
DMSO / DMSO	100 mM	0.0257 mL	0.1287 mL	0.2575 mL	0.6436 mL

Celecoxib-d₇ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Celecoxib-d₇544686-21-7SC 58635-d₇COXCyclooxygenaseInhibitorinhibitorinhibit

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Celecoxib-d7 (Synonyms: SC 58635-d7)

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Complete Stock Solution Preparation Table

Celecoxib-d7 Related Classifications

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Celecoxib-d₇ (Synonyms: SC 58635-d₇)

Other Forms of Celecoxib-d₇:

Celecoxib-d₇ Related Antibodies

Celecoxib-d₇ Related Antibodies

Celecoxib-d₇ Related Classifications