2. GPCR/G Protein
  3. Guanylate Cyclase
  4. CFM 1571 hydrochloride

CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases.

For research use only. We do not sell to patients.

CFM 1571 hydrochloride Chemical Structure

CFM 1571 hydrochloride Chemical Structure

CAS No. : 1215548-30-3

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10 mg USD 980 Get quote
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Based on 1 publication(s) in Google Scholar

CFM 1571 hydrochloride Related Antibodies

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Description

CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases[1][2].

IC50 & Target
Molecular Weight

444.95

Formula

C23H29ClN4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(OCCCN(C)C)=NN1CC2=CC=CC=C2)NC3=CC=C(C=C3)OC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (224.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2474 mL 11.2372 mL 22.4744 mL
5 mM 0.4495 mL 2.2474 mL 4.4949 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2474 mL 11.2372 mL 22.4744 mL 56.1861 mL
5 mM 0.4495 mL 2.2474 mL 4.4949 mL 11.2372 mL
10 mM 0.2247 mL 1.1237 mL 2.2474 mL 5.6186 mL
15 mM 0.1498 mL 0.7491 mL 1.4983 mL 3.7457 mL
20 mM 0.1124 mL 0.5619 mL 1.1237 mL 2.8093 mL
25 mM 0.0899 mL 0.4495 mL 0.8990 mL 2.2474 mL
30 mM 0.0749 mL 0.3746 mL 0.7491 mL 1.8729 mL
40 mM 0.0562 mL 0.2809 mL 0.5619 mL 1.4047 mL
50 mM 0.0449 mL 0.2247 mL 0.4495 mL 1.1237 mL
60 mM 0.0375 mL 0.1873 mL 0.3746 mL 0.9364 mL
80 mM 0.0281 mL 0.1405 mL 0.2809 mL 0.7023 mL
100 mM 0.0225 mL 0.1124 mL 0.2247 mL 0.5619 mL
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CFM 1571 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFM 15711215548-30-3CFM1571CFM-1571Guanylate Cyclasenitric oxide receptorsoluble guanylate cyclasesGCNOsignal-transductioncardiovascularInhibitorinhibitorinhibit

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