2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. CGP7930

CGP7930 (3-(3’,5’-Di-tert-butyl-4’-hydroxy) phenyl-2, 2-dimethylpropanol) is a positive metabotropic GABAB receptor allosteric modulator. CGP7930 enhances the inhibitory effect of l-baclofen on the oscillatory activity of cultured cortical neurons.

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CGP7930 Chemical Structure

CGP7930 Chemical Structure

CAS No. : 57717-80-3

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Based on 1 publication(s) in Google Scholar

CGP7930 Related Antibodies

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1 Publications Citing Use of MCE CGP7930

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Description

CGP7930 (3-(3’,5’-Di-tert-butyl-4’-hydroxy) phenyl-2, 2-dimethylpropanol) is a positive metabotropic GABAB receptor allosteric modulator. CGP7930 enhances the inhibitory effect of l-baclofen on the oscillatory activity of cultured cortical neurons[1].

Molecular Weight

292.46

Formula

C19H32O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC(C)(C)CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 29.25 mg/mL (100.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4193 mL 17.0964 mL 34.1927 mL
5 mM 0.6839 mL 3.4193 mL 6.8385 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4193 mL 17.0964 mL 34.1927 mL 85.4818 mL
5 mM 0.6839 mL 3.4193 mL 6.8385 mL 17.0964 mL
10 mM 0.3419 mL 1.7096 mL 3.4193 mL 8.5482 mL
15 mM 0.2280 mL 1.1398 mL 2.2795 mL 5.6988 mL
20 mM 0.1710 mL 0.8548 mL 1.7096 mL 4.2741 mL
25 mM 0.1368 mL 0.6839 mL 1.3677 mL 3.4193 mL
30 mM 0.1140 mL 0.5699 mL 1.1398 mL 2.8494 mL
40 mM 0.0855 mL 0.4274 mL 0.8548 mL 2.1370 mL
50 mM 0.0684 mL 0.3419 mL 0.6839 mL 1.7096 mL
60 mM 0.0570 mL 0.2849 mL 0.5699 mL 1.4247 mL
80 mM 0.0427 mL 0.2137 mL 0.4274 mL 1.0685 mL
100 mM 0.0342 mL 0.1710 mL 0.3419 mL 0.8548 mL
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CGP7930 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP793057717-80-3CGP 7930CGP-7930GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorrat hippocampal CA1 area293 cellsGABABcortical neuronsofl-baclofenInhibitorinhibitorinhibit

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