2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. CH-0793076

CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (CH-0793076 TFA) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

CH-0793076 Chemical Structure

CH-0793076 Chemical Structure

CAS No. : 534605-78-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of CH-0793076:

CH-0793076 Related Antibodies

Top Publications Citing Use of Products

View All Topoisomerase Isoform Specific Products:

View All Isoforms
Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein)[1].

IC50 & Target[1]

Topoisomerase I

2.3 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
0.36 nM
Compound: 7c
Antiproliferative activity against human HCT116 cells after 3 days
Antiproliferative activity against human HCT116 cells after 3 days
[PMID: 19254843]
NCI-H460 IC50
2.3 nM
Compound: 7c
Antiproliferative activity against human NCI-H460 cells after 3 days
Antiproliferative activity against human NCI-H460 cells after 3 days
[PMID: 19254843]
PC-6 IC50
0.18 nM
Compound: 7c
Antiproliferative activity against human PC6 cells carrying pRC after 6 days
Antiproliferative activity against human PC6 cells carrying pRC after 6 days
[PMID: 19254843]
PC-6 IC50
0.35 nM
Compound: 7c
Antiproliferative activity against human PC6 expressing BCRP cells after 6 days
Antiproliferative activity against human PC6 expressing BCRP cells after 6 days
[PMID: 19254843]
QG-56 IC50
2.3 nM
Compound: 7c
Antiproliferative activity against human QG56 cells after 3 days
Antiproliferative activity against human QG56 cells after 3 days
[PMID: 19254843]
In Vitro

CH0793076 (TP3076) (6 days at 37°C) shows antiproliferative activity against PC-6/BCRP and PC-6/pRC cells, with IC50s of 0.35 and 0.18 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CH-0793076 Related Antibodies
In Vivo

TP300 (1-100 mg/kg; bolus intravenous injection once per week for 3 weeks, for a total of three doses), a water-soluble prodrug of CH0793076, shows more than 50% of tumor growth inhibition in all nine models, regardless of the expression of BCRP (WiDr, HT-29, NCI-H460 and AsPC-1, HCT116, COLO 201, HCT-15, Calu-6 and NCI-N87)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

458.51

Formula

C26H26N4O4
CAS No.
SMILES

O=C1[C@](O)(CC)C(C=C23)=C(CO1)C(N2CC(C3=N4)=C5N(CCCCC)C=NC6=C5C4=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CH-0793076 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CH-0793076534605-78-2TP3076CH0793076CH 0793076TP 3076TP-3076Topoisomerasebreastcancerresistancemetaboliteantiproliferativeanti-cancertoxicitycolorectalInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CH-0793076
Cat. No.:
HY-107096
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.