Chaparrinone

Cat. No.: HY-N12151: FAQs
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Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC₅₀: 0.037 and 0.34 μg/mL respectively).

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Chaparrinone Chemical Structure

CAS No. : 22611-34-3

Size	Stock	Quantity
1 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	0.8 μg/mL Compound: chaparrinone	Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
Hep 3B2	IC₅₀	2.17 μM Compound: 4	Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HepG2	IC₅₀	> 50 μM Compound: 4	Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HepG2	IC₅₀	1.2 μM Compound: 4	Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HL-60	IC₅₀	1.2 μM Compound: 26	Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter	[PMID: 11754601]
HL-60	EC₅₀	2.4 μM Compound: 26	Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay	[PMID: 11754601]
HL-60	IC₅₀	5 μM Compound: 26	Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay	[PMID: 11754601]
K562	IC₅₀	1.8 μg/mL Compound: chaparrinone	Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
KB	ED₅₀	0.025 μg/mL Compound: 2, NSC-288754	Cytotoxicity against human KB cells by NCI method Cytotoxicity against human KB cells by NCI method	[PMID: 6875576]
KB	IC₅₀	1.2 μg/mL Compound: chaparrinone	Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
P388	IC₅₀	0.92 μg/mL Compound: 6	Cytotoxicity against mouse P388 cells after 3 days by MTT assay Cytotoxicity against mouse P388 cells after 3 days by MTT assay	[PMID: 9644063]
SK-OV-3	IC₅₀	0.5 μg/mL Compound: chaparrinone	Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
Vero	IC₅₀	1.5 μg/mL Compound: chaparrinone	Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay	[PMID: 8984156]

Molecular Weight

378.42

Formula

C₂₀H₂₆O₇

CAS No.

22611-34-3

SMILES

C[C@@]12[C@]3([H])[C@@]45[C@@](OC(C[C@@]4([H])[C@H]([C@H]([C@@]3(OC5)O)O)C)=O)([H])C[C@@]1([H])C(C)=CC([C@H]2O)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57(8):1205-8. [Content Brief]

[2]. François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28(4):635-40. [Content Brief]

Chaparrinone Related Classifications

Infection

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chaparrinone22611-34-3ParasiteantimalarialcytotoxicquassinoidInhibitorinhibitorinhibit

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