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  4. Simaroubaceae

Simaroubaceae

 

Simaroubaceae (78):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19543
    Brusatol 14907-98-3 99.89%
    Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent. Brusatol increases cellular apoptosis.
    Brusatol
  • HY-N1943
    Ailanthone 981-15-7 99.76%
    Ailanthone (Δ13-Dehydrochaparrinone) is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69 nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309 nM).
    Ailanthone
  • HY-N3014
    Bruceine D 21499-66-1 99.53%
    Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity. Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L.
    Bruceine D
  • HY-N0840
    Bruceantin 41451-75-6 99.94%
    Bruceantin(NSC165563) is first isolated from Brucea javanica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.
    Bruceantin
  • HY-N0841
    Bruceine A 25514-31-2 98.01%
    Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.
    Bruceine A
  • HY-W130965
    1-Formyl-beta-carboline 20127-63-3
    1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway.
    1-Formyl-beta-carboline
  • HY-N12875
    Ailancoumarin E
    Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC50 of 14.21 μM.
    Ailancoumarin E
  • HY-N1581R
    Quassin (Standard) 76-78-8
    Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity.
    Quassin (Standard)
  • HY-111806
    3,7,4'-Trihydroxyflavone 2034-65-3 99.44%
    3,7,4'-Trihydroxyflavone, isolated from Rhus javanica var. roxburghiana, is a flavonoid with DNA strand-scission activity.
    3,7,4'-Trihydroxyflavone
  • HY-N8146
    Bruceantinol 53729-52-5 98.89%
    Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc.
    Bruceantinol
  • HY-N4210
    Yadanziolide A 95258-14-3 99.42%
    Yadanziolide A, isolated from the cultivated dry seeds of Brucea javanica, has strong antiviral activities with IC50 of 5.5 μM against tobacco mosaic virus. Yadanziolide A shows significant antitumor effects.
    Yadanziolide A
  • HY-N1581
    Quassin 76-78-8 ≥98.0%
    Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity.
    Quassin
  • HY-N3013
    Bruceine B 25514-29-8 99.60%
    Bruceine B inhibits protein synthesis and nucleic acid synthesis.
    Bruceine B
  • HY-N10926
    (+)-Glaucarubinone 1259-86-5
    (+)-Glaucarubinone is a potent AP-1 (activator protein-1) inhibitor with an EC50 value of 0.13 µM. (+)-Glaucarubinone shows noncytotoxic.
    (+)-Glaucarubinone
  • HY-N10450
    Kumujian A 72755-19-2 98.32%
    Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL).
    Kumujian A
  • HY-N1203
    (5α)-Stigmastane-3,6-dione 22149-69-5
    (5α)-Stigmastane-3,6-dione is a naturally occurring sterol that could be isolated from fruits of Ailanthus altissima Swingle. Antimicrobial Activity..
    (5α)-Stigmastane-3,6-dione
  • HY-N3710
    Dehydrocrenatidine 65236-62-6 ≥98.0%
    Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain.
    Dehydrocrenatidine
  • HY-N4257
    Yadanzioside A 95258-15-4 ≥98.0%
    Yadanziolide A, a quassinoid glycoside from Brucea javanica, has antitumor activity.
    Yadanzioside A
  • HY-N7190
    Yadanzioside F 95258-11-0 ≥98.0%
    Yadanzioside F is one of the toxic components found in Brucea javanica. Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties.
    Yadanzioside F
  • HY-N7532
    Yadanzioside I 99132-95-3
    Yadanzioside I is a potent anti-tobacco mosaic virus (TMV) quassinoid with an IC50 of 4.22 μM.
    Yadanzioside I