Chloroquine-d₅

Cat. No.: HY-17589AS Purity: 100.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Chloroquine-d₅ is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

For research use only. We do not sell to patients.

Chloroquine-d<sub>5</sub> Chemical Structure

Chloroquine-d₅ Chemical Structure

CAS No. : 1854126-41-2

Size	Price	Stock	Quantity
1 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 970	Get quote	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Chloroquine-d₅:

1 Publications Citing Use of MCE Chloroquine-d₅

•Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. [Abstract]

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

View All Toll-like Receptor (TLR) Isoform Specific Products:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

View All HIV Isoform Specific Products:

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HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]^[2][3]^[5]

Plasmodium

Malaria

TLRs

SARS-COV-2

HIV-1

Molecular Weight

324.90

Formula

C₁₈H₂₁D₅ClN₃

CAS No.

1854126-41-2

Unlabeled CAS

54-05-7

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN(CC)C([2H])([2H])C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (153.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0779 mL	15.3894 mL	30.7787 mL
5 mM	0.6156 mL	3.0779 mL	6.1557 mL
10 mM	0.3078 mL	1.5389 mL	3.0779 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 100.00%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (245 KB) LCMS (179 KB)

Handling Instructions (2659 KB)

References

[1]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. [Content Brief]

[2]. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672. [Content Brief]

[3]. Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626. [Content Brief]

[4]. Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55(4):105932. [Content Brief]

[5]. Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20(3):131-135. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	3.0779 mL	15.3894 mL	30.7787 mL	76.9468 mL
	5 mM	0.6156 mL	3.0779 mL	6.1557 mL	15.3894 mL
	10 mM	0.3078 mL	1.5389 mL	3.0779 mL	7.6947 mL
	15 mM	0.2052 mL	1.0260 mL	2.0519 mL	5.1298 mL
	20 mM	0.1539 mL	0.7695 mL	1.5389 mL	3.8473 mL
	25 mM	0.1231 mL	0.6156 mL	1.2311 mL	3.0779 mL
	30 mM	0.1026 mL	0.5130 mL	1.0260 mL	2.5649 mL
	40 mM	0.0769 mL	0.3847 mL	0.7695 mL	1.9237 mL
	50 mM	0.0616 mL	0.3078 mL	0.6156 mL	1.5389 mL
	60 mM	0.0513 mL	0.2565 mL	0.5130 mL	1.2824 mL
	80 mM	0.0385 mL	0.1924 mL	0.3847 mL	0.9618 mL
	100 mM	0.0308 mL	0.1539 mL	0.3078 mL	0.7695 mL