2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Cholestenone-d5

Cholestenone-d5  (Synonyms: 4-Cholesten-3-one-d5)

Cat. No.: HY-113365S Purity: ≥99.0%
SDS COA Handling Instructions

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Cholestenone-d5 is the deuterium labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2][3].

For research use only. We do not sell to patients.

Cholestenone-d<sub>5</sub> Chemical Structure

Cholestenone-d5 Chemical Structure

CAS No. : 72560-60-2

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1 mg USD 75 In-stock
5 mg USD 180 In-stock
10 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cholestenone-d5:

Cholestenone-d5 Related Antibodies

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  • Purity & Documentation

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Description

Cholestenone-d5 is the deuterium labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cholestenone-d5 Related Antibodies
Molecular Weight

389.67

Formula

C27H39D5O
CAS No.
Unlabeled CAS

601-57-0
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (128.31 mM; Need ultrasonic)

Ethanol : 50 mg/mL (128.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5663 mL 12.8314 mL 25.6627 mL
5 mM 0.5133 mL 2.5663 mL 5.1325 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / Ethanol 1 mM 2.5663 mL 12.8314 mL 25.6627 mL 64.1568 mL
5 mM 0.5133 mL 2.5663 mL 5.1325 mL 12.8314 mL
10 mM 0.2566 mL 1.2831 mL 2.5663 mL 6.4157 mL
15 mM 0.1711 mL 0.8554 mL 1.7108 mL 4.2771 mL
20 mM 0.1283 mL 0.6416 mL 1.2831 mL 3.2078 mL
25 mM 0.1027 mL 0.5133 mL 1.0265 mL 2.5663 mL
30 mM 0.0855 mL 0.4277 mL 0.8554 mL 2.1386 mL
40 mM 0.0642 mL 0.3208 mL 0.6416 mL 1.6039 mL
50 mM 0.0513 mL 0.2566 mL 0.5133 mL 1.2831 mL
60 mM 0.0428 mL 0.2139 mL 0.4277 mL 1.0693 mL
80 mM 0.0321 mL 0.1604 mL 0.3208 mL 0.8020 mL
100 mM 0.0257 mL 0.1283 mL 0.2566 mL 0.6416 mL
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Cholestenone-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cholestenone-d572560-60-24-Cholesten-3-one-d5Endogenous MetaboliteInhibitorinhibitorinhibit

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