Choline hydroxide, 44 wt.% in water

Cat. No.: HY-Y1242: FAQs
Data Sheet SDS COA Handling Instructions

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Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism .

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Choline hydroxide, 44 wt.% in water Chemical Structure

CAS No. : 123-41-1

Size	Price	Stock	Quantity
Solvent
10 g（3.64 M * 22.73 mL in Water）	USD 25	In-stock	Estimated Time of Arrival: December 31
Solvent
25 g（3.64 M * 56.82 mL in Water）	USD 40	In-stock	Estimated Time of Arrival: December 31

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Other Forms of Choline hydroxide, 44 wt.% in water:

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Biological Activity
Purity & Documentation
References
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Description	Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism ^[1]^[2]^[3].
In Vitro	Choline hydroxide can be used as the standard alkaline, and (0.5 M) results pH_o shifts rapidly to 7.59 in a sucrose medium (pH at 7.08)^[1]. Choline hydroxide (0.1-0.5 g/mL), together with organic carboxylic acids, makes preparation of ionic liquids, which is used for prepare a ionic liquid-reverse micelle drug-carrying delivery system and involves in epidermal desensitization research^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Choline hydroxide, 44 wt.% in water Related Antibodies
Molecular Weight	121.18
Formula	C₅H₁₅NO₂
CAS No.	123-41-1
Appearance	Liquid
Color	Colorless to light yellow
SMILES	OCC[N+](C)(C)C.[OH-]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Solution, -20°C, 2 years
Solvent & Solubility	In Vitro: H₂O : 200 mg/mL (1650.44 mM; Need ultrasonic) DMSO : 100 mg/mL (825.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Molarity Calculator Dilution Calculator Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Mass = Concentration × Volume × Molecular Weight * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) This equation is commonly abbreviated as: C₁V₁ = C₂V₂ Concentration _(start) C1 × Volume _(start) V1 = Concentration _(final) C2 × Volume _(final) V2 In Vivo: Select the appropriate dissolution method based on your experimental animal and administration route. For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents: To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day. The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution. Protocol 1 Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline Solubility: ≥ 2.5 mg/mL (20.63 mM); Clear solution This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL. Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution. Protocol 2 Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline) Solubility: ≥ 2.5 mg/mL (20.63 mM); Clear solution This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear. In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kg Animal weight (per animal) g Dosing volume (per animal) μL Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details. The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE). Tel: 609-228-6898 E-mail: sales@medchemexpress.com Technical Support: tech@medchemexpress.com
Purity & Documentation	Select Batch: Data Sheet (270 KB) SDS (476 KB) COA (244 KB) HNMR (128 KB) Handling Instructions (2659 KB)
References	[1]. Mitchell P, et al. Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria. Eur J Biochem. 1969 Feb;7(4):471-84. [Content Brief] [2]. Ding Y, et al. An ionic liquid-reverse micelle drug delivery system for epidermal desensitization therapy and its preparation method and application: China, CN113975224. 2022-01-28. [3]. Wang F, et al. Short communication: Effects of dietary deoiled soy lecithin supplementation on circulating choline and choline metabolites, and the plasma phospholipid profile in Holstein cows fed palm fat. J Dairy Sci. 2021 Feb;104(2):1838-1845. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	8.2522 mL	41.2609 mL	82.5219 mL	206.3047 mL
	5 mM	1.6504 mL	8.2522 mL	16.5044 mL	41.2609 mL
	10 mM	0.8252 mL	4.1261 mL	8.2522 mL	20.6305 mL
	15 mM	0.5501 mL	2.7507 mL	5.5015 mL	13.7536 mL
	20 mM	0.4126 mL	2.0630 mL	4.1261 mL	10.3152 mL
	25 mM	0.3301 mL	1.6504 mL	3.3009 mL	8.2522 mL
	30 mM	0.2751 mL	1.3754 mL	2.7507 mL	6.8768 mL
	40 mM	0.2063 mL	1.0315 mL	2.0630 mL	5.1576 mL
	50 mM	0.1650 mL	0.8252 mL	1.6504 mL	4.1261 mL
	60 mM	0.1375 mL	0.6877 mL	1.3754 mL	3.4384 mL
	80 mM	0.1032 mL	0.5158 mL	1.0315 mL	2.5788 mL
	100 mM	0.0825 mL	0.4126 mL	0.8252 mL	2.0630 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.