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  5. Chrysene

Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties.

For research use only. We do not sell to patients.

Chrysene Chemical Structure

Chrysene Chemical Structure

CAS No. : 218-01-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Chrysene:

Chrysene Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Chrysene

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Description

Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties[1].

In Vivo

Chrysene can be used in animal modeling to create hepatic tumor models.

Induction of liver tumors[2][3][4][5]
Background
Chrysene exerts its carcinogenic effects by being metabolized by monooxygenases into carcinogenic metabolites (epoxides and their hydrolysis products). Additionally, studies have shown that chrysene may induce oxidative liver damage, including liver DNA damage and glutathione depletion, by activating the aryl hydrocarbon receptor (AhR), which may be related to its carcinogenic risk[2][3][4][5]
.
Specific Mmodeling Methods
Mice: CD-1 • male • 1, 8, and 15 days old
Administration: 700 or 2800 nmol/Mouse • ip • administered on postnatal days 1, 8, and 15
Note
(1) Chrysene is dissolved in DMSO, and the total amount of Chrysene injected intraperitoneally into each mouse is either 700 or 2800 nmol. The distribution of the three injection doses is as follows:
On Day 1, inject 100 or 400 nmol of Chrysene, with a DMSO volume of 10 μL.
On Day 8, inject 200 or 800 nmol of Chrysene, with a DMSO volume of 20 μL.
On Day 15, inject 400 or 1600 nmol of Chrysene, with a DMSO volume of 40 μL.
(2) The administration is performed under dim light, and the mice are euthanized one year later to determine the incidence of liver tumors.
Modeling Indicators
Histological changes: An increase in the incidence of adenomas and carcinomas in the liver.
Correlated Product(s): /
Opposite Product(s): /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

228.29

Formula

C18H12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C12=CC=CC=C1C=CC3=C4C=CC=CC4=CC=C23
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (8.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3804 mL 21.9020 mL 43.8039 mL
5 mM 0.8761 mL 4.3804 mL 8.7608 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.81%

SDS (562 KB)

COA (251 KB) HNMR (163 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3804 mL 21.9020 mL 43.8039 mL 109.5098 mL
5 mM 0.8761 mL 4.3804 mL 8.7608 mL 21.9020 mL
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Chrysene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chrysene218-01-9OthersInhibitorinhibitorinhibit

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