2. Induced Disease Models Products
  3. Cancer Models
  4. Liver Cancer Models

Liver Cancer Models

Liver Cancer Models (6):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N6615
    Aflatoxin B1 1162-65-8 99.96%
    Aflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) primarily induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. In the body, Aflatoxin B1 (AFB1) can cause damage to the intestines and kidneys and has some teratogenic effects.
    Aflatoxin B1
  • HY-N7434
    N-Nitrosodiethylamine 55-18-5 99.97%
    N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
    N-Nitrosodiethylamine
  • HY-Y0698
    Thioacetamide 62-55-5 ≥98.0%
    Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model.
    Thioacetamide
  • HY-121107
    Chrysene 218-01-9 99.81%
    Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties.
    Chrysene
  • HY-131123
    N-Nitrosomorpholine 59-89-2 99.91%
    N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen.
    N-Nitrosomorpholine
  • HY-W025785
    Methyl yellow 60-11-7
    Methyl yellow (Solvent Yellow 2) is a pH indicator. Methyl yellow appears red at low pH, and becomes yellow above pH 4.0.
    Methyl yellow