Ciglitazone (Synonyms: ADD-3878; U-63287)

Name: Ciglitazone
Brand: MedChemExpress
SKU: HY-W011220
Rating: 4.5 (1 reviews)

Cat. No.: HY-W011220 Purity: 98.89%: FAQs
Data Sheet SDS COA Handling Instructions

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Ciglitazone is a potent and selective PPARγ agonist (EC₅₀=3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells.

For research use only. We do not sell to patients.

Ciglitazone Chemical Structure

CAS No. : 74772-77-3

Size	Price	Stock	Quantity
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 176	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Ciglitazone

•Acta Pharm Sin B. 2024 Jun 20.

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PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	10 μM Compound: Ciglitazone	Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis	[PMID: 20966043]
HepG2	EC₅₀	14.1 μM Compound: Ciglitazone	Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis	[PMID: 20966043]
LNCaP	IC₅₀	60 μM Compound: 1, Ciglitazone	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay in presence of 10% FBS Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay in presence of 10% FBS	[PMID: 22468970]
LNCaP	IC₅₀	78 μM Compound: 1, Ciglitazone	Inhibition of glucose transporter in human LNCAP cells assessed as blocking of [3H]-2-DG uptake after 30 mins by scintillation counting Inhibition of glucose transporter in human LNCAP cells assessed as blocking of [3H]-2-DG uptake after 30 mins by scintillation counting	[PMID: 22468970]
NIH3T3	EC₅₀	14.9 μM Compound: ciglitazone	Agonist activity at human PPARgamma expressed in mouse NIH/3T3 cells assessed as receptor activation after 16 hrs by luciferase based reporter gene assay Agonist activity at human PPARgamma expressed in mouse NIH/3T3 cells assessed as receptor activation after 16 hrs by luciferase based reporter gene assay	[PMID: 11975517]
PC-12	IC₅₀	20 μM Compound: Ciglitazone	Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay	[PMID: 15109648]

In Vitro

Ciglitazone (0-20 μM; 24 hours) induces apoptosis through PPAR-independent mechanism. Ciglitazone causes generation of ROS and an increase in intracellular Ca²⁺^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In C57BL/6J-ob/ob mice, Ciglitazone (100 mg/kg/day; 2 days) elicits a drastic fall in blood glucose. Regranulation of islet beta-cells and increased pancreatic insulin content are observed in ob/ob mice treated for 41-44 days with 100 mg/kg/day Ciglitazone^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

333.45

Formula

C₁₈H₂₃NO₃S

CAS No.

74772-77-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)SC(CC2=CC=C(OCC3(C)CCCCC3)C=C2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (299.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9990 mL	14.9948 mL	29.9895 mL
5 mM	0.5998 mL	2.9990 mL	5.9979 mL
10 mM	0.2999 mL	1.4995 mL	2.9990 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.89%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (246 KB) LCMS (264 KB)

Handling Instructions (2659 KB)

References

[1]. Willson TM, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996;39(3):665-668. [Content Brief]

[2]. Kim DH, et al. Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells. Biomol Ther (Seoul). 2015;23(1):71-76. [Content Brief]

[3]. Chang AY, et al. Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes. 1983;32(9):830-838. [Content Brief]

[4]. Kwon CH, et al. Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca(2+) in opossum kidney cells. Toxicology. 2009;257(1-2):1-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9990 mL	14.9948 mL	29.9895 mL	74.9738 mL
	5 mM	0.5998 mL	2.9990 mL	5.9979 mL	14.9948 mL
	10 mM	0.2999 mL	1.4995 mL	2.9990 mL	7.4974 mL
	15 mM	0.1999 mL	0.9997 mL	1.9993 mL	4.9983 mL
	20 mM	0.1499 mL	0.7497 mL	1.4995 mL	3.7487 mL
	25 mM	0.1200 mL	0.5998 mL	1.1996 mL	2.9990 mL
	30 mM	0.1000 mL	0.4998 mL	0.9997 mL	2.4991 mL
	40 mM	0.0750 mL	0.3749 mL	0.7497 mL	1.8743 mL
	50 mM	0.0600 mL	0.2999 mL	0.5998 mL	1.4995 mL
	60 mM	0.0500 mL	0.2499 mL	0.4998 mL	1.2496 mL
	80 mM	0.0375 mL	0.1874 mL	0.3749 mL	0.9372 mL
	100 mM	0.0300 mL	0.1499 mL	0.2999 mL	0.7497 mL

Ciglitazone Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ciglitazone74772-77-3ADD-3878 U-63287ADD3878ADD 3878U63287U 63287U-63287PPARPeroxisome proliferator-activated receptorshypoglycemic agentorally activefood intakeAIFth17 cellsInhibitorinhibitorinhibit

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Ciglitazone (Synonyms: ADD-3878; U-63287)

Customer Review

Ciglitazone Related Antibodies

1 Publications Citing Use of MCE Ciglitazone

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Ciglitazone Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Ciglitazone Related Classifications

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