2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Cirsimarin

Cirsimarin is a potent antilipogenic flavonoid isolated from Microtea debilis. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on adenosin A1 receptor and its inhibitory effect on phosphodiesterase.

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Cirsimarin Chemical Structure

Cirsimarin Chemical Structure

CAS No. : 13020-19-4

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1 mg USD 130 In-stock
5 mg USD 310 In-stock
10 mg USD 510 In-stock
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Based on 1 publication(s) in Google Scholar

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Cirsimarin Related Antibodies

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Description

Cirsimarin is a potent antilipogenic flavonoid isolated from Microtea debilis. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on adenosin A1 receptor and its inhibitory effect on phosphodiesterase[1].

IC50 & Target

Phosphodiesterase[1];
Adenosin A1 receptor[1]
Molecular Weight

476.43

Formula

C23H24O11
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C=C(C2=CC=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C=C2)OC4=CC(OC)=C(OC)C(O)=C14
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (104.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0989 mL 10.4947 mL 20.9894 mL
5 mM 0.4198 mL 2.0989 mL 4.1979 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0989 mL 10.4947 mL 20.9894 mL 52.4736 mL
5 mM 0.4198 mL 2.0989 mL 4.1979 mL 10.4947 mL
10 mM 0.2099 mL 1.0495 mL 2.0989 mL 5.2474 mL
15 mM 0.1399 mL 0.6996 mL 1.3993 mL 3.4982 mL
20 mM 0.1049 mL 0.5247 mL 1.0495 mL 2.6237 mL
25 mM 0.0840 mL 0.4198 mL 0.8396 mL 2.0989 mL
30 mM 0.0700 mL 0.3498 mL 0.6996 mL 1.7491 mL
40 mM 0.0525 mL 0.2624 mL 0.5247 mL 1.3118 mL
50 mM 0.0420 mL 0.2099 mL 0.4198 mL 1.0495 mL
60 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8746 mL
80 mM 0.0262 mL 0.1312 mL 0.2624 mL 0.6559 mL
100 mM 0.0210 mL 0.1049 mL 0.2099 mL 0.5247 mL
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Cirsimarin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cirsimarin13020-19-4Phosphodiesterase (PDE)AntilipogenicflavonoidadiposeadenosineA1receptorInhibitorinhibitorinhibit

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