2. Academic Validation
  3. A comprehensive review on biological properties of citrinin

A comprehensive review on biological properties of citrinin

  • Food Chem Toxicol. 2017 Dec;110:130-141. doi: 10.1016/j.fct.2017.10.002.
José Williams Gomes de Oliveira Filho 1,  Muhammad Torequl Islam 2,  Eunus S Ali 3,  Shaikh Jamal Uddin 4,  Jose Victor de Oliveira Santos 5,  Marcus Vinícius Oliveira Barros de Alencar 6,  Antonio Luiz Gomes Júnior 7,  Márcia Fernanda Correia Jardim Paz 6,  Maria Dos Remédios Mendes de Brito 5,  João Marcelo de Castro E Sousa 8,  Subrata Shaw 9,  Maria das Graças Freire de Medeiros 8,  Sandra Maria Mendes de Moura Dantas 10,  Hercília Maria Lins Rolim 11,  Paulo Michel Pinheiro Ferreira 12,  Mohammad Amjad Kamal 13,  Magdalena D Pieczynska 14,  Niranjan Das 15,  Vijai K Gupta 16,  Andrei Mocan 17,  Teresinha de Jesus Aguiar Dos Santos Andrade 18,  Brahma Nand Singh 19,  Siddhartha K Mishra 20,  Atanas G Atanasov 21,  Ana Amélia de Carvalho Melo-Cavalcante 22
Affiliations

Affiliations

  • 1 Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, Teresina, Piauí 64.049-550, Brazil.
  • 2 Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil; Laboratory of Pharmaceutical Nanosystems - NANOSFAR, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil.
  • 3 Gaco Pharmaceuticals and Research Laboratory, Dhaka 1000, Bangladesh; School of Medicine, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia.
  • 4 Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh.
  • 5 Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil.
  • 6 Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, Teresina, Piauí 64.049-550, Brazil; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil.
  • 7 Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, Teresina, Piauí 64.049-550, Brazil; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil; Biomedicine Course, UNINOVAFAPI University Center, Teresina, Piauí, 64.073-505, Brazil.
  • 8 Department of Biological Sciences, Federal University of Piauí, Picos, PI 64.600-000, Brazil.
  • 9 Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • 10 Laboratory of Cytogenetics and Mutagenesis, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil.
  • 11 Laboratory of Pharmaceutical Nanosystems - NANOSFAR, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil.
  • 12 Department of Biophysics and Physiology, Universidade Federal do Piauí, Teresina, Brazil.
  • 13 King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia; Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, USA; Novel Global Community Educational Foundation, Australia.
  • 14 Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland.
  • 15 Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
  • 16 Department of Chemistry and Biotechnology, ERA Chair of Green Chemistry, School of Science, Tallinn University of Technology, 12618 Tallinn, Estonia.
  • 17 Department of Pharmaceutical Botany, Iuliu Haţieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • 18 NIAC-Nucleus of Research Applied to Sciences-IFMA-Federal Institute of Education, Science and Technology ofMaranhão (Campus São Raimundo das MAngabeiras), Brazil.
  • 19 Herbal Nanobiotechnology Lab, Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226001, India.
  • 20 Cancer Biology Laboratory, School of Biological Sciences (Zoology), Dr. Harisingh Gour Central University, Sagar 470003, M.P., India. Electronic address: siddhartha.km@gmail.com.
  • 21 Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland; Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria. Electronic address: atanas.atanasov@univie.ac.at.
  • 22 Department of Chemistry, Netaji Subhas Mahavidyalaya, Udaipur 799114, Gomati Tripura, India.
PMID: 28993214 DOI: 10.1016/j.fct.2017.10.002
Abstract

Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several Fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive. It is still controversial what are the genotoxic and mutagenic effects of CIT. Until now, its toxic effect has been linked to the CIT-mediated oxidative stress and mitochondrial dysfunction in biological systems. However, the toxicity strongly depends on its concentration, route, frequency and time of exposure, as well as from the used test systems. Besides the toxic effects, CIT is also reported to possess a broad spectrum of bioactivities, including Antibacterial, Antifungal, and potential Anticancer and neuro-protective effects in vitro. This systematic review presents the current state of CIT research with emphasis on its bioactivity profile.

Keywords

Anticancer; Antimicrobial; Citrinin; Genotoxicity; Mycotoxins; Toxicity.

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