2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. CL 218872

CL 218872 is a selective and orally active benzodiazepine of α1 subunit-containing GABAAreceptor with a Ki of 130 nM. CL 218872 exerts anxiolytic and anticonvulsant in vivo.

For research use only. We do not sell to patients.

CL 218872 Chemical Structure

CL 218872 Chemical Structure

CAS No. : 66548-69-4

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25 mg USD 105 In-stock
50 mg USD 180 In-stock
100 mg USD 300 In-stock
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Description

CL 218872 is a selective and orally active benzodiazepine of α1 subunit-containing GABAAreceptor with a Ki of 130 nM. CL 218872 exerts anxiolytic and anticonvulsant in vivo[1].

Molecular Weight

278.23

Formula

C13H9F3N4
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

FC(C1=CC(C2=NN3C(C=C2)=NN=C3C)=CC=C1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (59.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5941 mL 17.9707 mL 35.9415 mL
5 mM 0.7188 mL 3.5941 mL 7.1883 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5941 mL 17.9707 mL 35.9415 mL 89.8537 mL
5 mM 0.7188 mL 3.5941 mL 7.1883 mL 17.9707 mL
10 mM 0.3594 mL 1.7971 mL 3.5941 mL 8.9854 mL
15 mM 0.2396 mL 1.1980 mL 2.3961 mL 5.9902 mL
20 mM 0.1797 mL 0.8985 mL 1.7971 mL 4.4927 mL
25 mM 0.1438 mL 0.7188 mL 1.4377 mL 3.5941 mL
30 mM 0.1198 mL 0.5990 mL 1.1980 mL 2.9951 mL
40 mM 0.0899 mL 0.4493 mL 0.8985 mL 2.2463 mL
50 mM 0.0719 mL 0.3594 mL 0.7188 mL 1.7971 mL
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CL 218872 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL 21887266548-69-4CL218872CL-218872GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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