2. Anti-infection
  3. Fungal
  4. Climbazole-d4

Climbazole-d4  (Synonyms: BAY-e 6975-d4)

Cat. No.: HY-B1151S Purity: 99.91%
COA Handling Instructions

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Climbazole-d4 is the deuterium labeled Climbazole. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450[2].

For research use only. We do not sell to patients.

Climbazole-d<sub>4</sub> Chemical Structure

Climbazole-d4 Chemical Structure

CAS No. : 1185117-79-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Climbazole-d4:

Climbazole-d4 Related Antibodies

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Description

Climbazole-d4 is the deuterium labeled Climbazole. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Climbazole-d4 Related Antibodies
Molecular Weight

296.79

Formula

C15H13D4ClN2O2
CAS No.
Unlabeled CAS

38083-17-9
Appearance

Solid

Color

White to off-white

SMILES

ClC(C([2H])=C1[2H])=C([2H])C([2H])=C1OC(N2C=CN=C2)C(C(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (336.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3694 mL 16.8469 mL 33.6939 mL
5 mM 0.6739 mL 3.3694 mL 6.7388 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3694 mL 16.8469 mL 33.6939 mL 84.2346 mL
5 mM 0.6739 mL 3.3694 mL 6.7388 mL 16.8469 mL
10 mM 0.3369 mL 1.6847 mL 3.3694 mL 8.4235 mL
15 mM 0.2246 mL 1.1231 mL 2.2463 mL 5.6156 mL
20 mM 0.1685 mL 0.8423 mL 1.6847 mL 4.2117 mL
25 mM 0.1348 mL 0.6739 mL 1.3478 mL 3.3694 mL
30 mM 0.1123 mL 0.5616 mL 1.1231 mL 2.8078 mL
40 mM 0.0842 mL 0.4212 mL 0.8423 mL 2.1059 mL
50 mM 0.0674 mL 0.3369 mL 0.6739 mL 1.6847 mL
60 mM 0.0562 mL 0.2808 mL 0.5616 mL 1.4039 mL
80 mM 0.0421 mL 0.2106 mL 0.4212 mL 1.0529 mL
100 mM 0.0337 mL 0.1685 mL 0.3369 mL 0.8423 mL
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Climbazole-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Climbazole-d41185117-79-6BAY-e 6975-d4FungalInhibitorinhibitorinhibit

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