2. Others Anti-infection
  3. Isotope-Labeled Compounds Bacterial Antibiotic Parasite
  4. Clindamycin-13C,d3

Clindamycin-13C,d3 is the 13C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2][3].

For research use only. We do not sell to patients.

Clindamycin-<sup>13</sup>C,d<sub>3</sub> Chemical Structure

Clindamycin-13C,d3 Chemical Structure

CAS No. : 2140264-63-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Clindamycin-13C,d3:

Clindamycin-13C,d3 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

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Description

Clindamycin-13C,d3 is the 13C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2][3].

IC50 & Target

Plasmodium

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clindamycin-13C,d3 Related Antibodies
Molecular Weight

428.99

Formula

C1713CH30D3ClN2O5S
CAS No.
Unlabeled CAS

18323-44-9
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1C[C@H](CN1[13C]([2H])([2H])[2H])CCC)N[C@@H]([C@@]2([H])O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (291.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 125 mg/mL (291.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3311 mL 11.6553 mL 23.3106 mL
5 mM 0.4662 mL 2.3311 mL 4.6621 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.3311 mL 11.6553 mL 23.3106 mL 58.2764 mL
5 mM 0.4662 mL 2.3311 mL 4.6621 mL 11.6553 mL
10 mM 0.2331 mL 1.1655 mL 2.3311 mL 5.8276 mL
15 mM 0.1554 mL 0.7770 mL 1.5540 mL 3.8851 mL
20 mM 0.1166 mL 0.5828 mL 1.1655 mL 2.9138 mL
25 mM 0.0932 mL 0.4662 mL 0.9324 mL 2.3311 mL
30 mM 0.0777 mL 0.3885 mL 0.7770 mL 1.9425 mL
40 mM 0.0583 mL 0.2914 mL 0.5828 mL 1.4569 mL
50 mM 0.0466 mL 0.2331 mL 0.4662 mL 1.1655 mL
60 mM 0.0389 mL 0.1943 mL 0.3885 mL 0.9713 mL
80 mM 0.0291 mL 0.1457 mL 0.2914 mL 0.7285 mL
100 mM 0.0233 mL 0.1166 mL 0.2331 mL 0.5828 mL
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Clindamycin-13C,d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clindamycin-13C,d32140264-63-5Isotope-Labeled CompoundsBacterialAntibioticParasiteInhibitorinhibitorinhibit

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