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Clonixin  (Synonyms: SCH-10304)

Cat. No.: HY-121235 Purity: ≥98.0%
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Clonixin (SCH-10304) is an orally active non-steroidal anti-inflammatory agent in rodents.

For research use only. We do not sell to patients.

Clonixin Chemical Structure

Clonixin Chemical Structure

CAS No. : 17737-65-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO USD 50 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Clonixin:

Clonixin Related Antibodies

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  • Purity & Documentation

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Description

Clonixin (SCH-10304) is an orally active non-steroidal anti-inflammatory agent in rodents[1].

Cellular Effect
Cell Line Type Value Description References
Bone marrow cell EC50
> 20 μM
Compound: Clonixin
Induction of bone marrow cell differentiation isolated from ER-HOXA9 fusion protein expressed mouse harboring GFP-lysozyme assessed as upregulation of CD11b/MAC1 after 4 days by flow cytometry
Induction of bone marrow cell differentiation isolated from ER-HOXA9 fusion protein expressed mouse harboring GFP-lysozyme assessed as upregulation of CD11b/MAC1 after 4 days by flow cytometry
[PMID: 27994748]
THP-1 EC50
> 20 μM
Compound: Clonixin
Induction of human THP1 cell differentiation after 4 days by flow cytometry
Induction of human THP1 cell differentiation after 4 days by flow cytometry
[PMID: 27994748]
U-937 EC50
> 20 μM
Compound: Clonixin
Induction of human U937 cell differentiation after 4 days by flow cytometry
Induction of human U937 cell differentiation after 4 days by flow cytometry
[PMID: 27994748]
Molecular Weight

262.69

Formula

C13H11ClN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CN=C1NC2=CC=CC(Cl)=C2C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (380.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8068 mL 19.0338 mL 38.0677 mL
5 mM 0.7614 mL 3.8068 mL 7.6135 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (9.52 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8068 mL 19.0338 mL 38.0677 mL 95.1692 mL
5 mM 0.7614 mL 3.8068 mL 7.6135 mL 19.0338 mL
10 mM 0.3807 mL 1.9034 mL 3.8068 mL 9.5169 mL
15 mM 0.2538 mL 1.2689 mL 2.5378 mL 6.3446 mL
20 mM 0.1903 mL 0.9517 mL 1.9034 mL 4.7585 mL
25 mM 0.1523 mL 0.7614 mL 1.5227 mL 3.8068 mL
30 mM 0.1269 mL 0.6345 mL 1.2689 mL 3.1723 mL
40 mM 0.0952 mL 0.4758 mL 0.9517 mL 2.3792 mL
50 mM 0.0761 mL 0.3807 mL 0.7614 mL 1.9034 mL
60 mM 0.0634 mL 0.3172 mL 0.6345 mL 1.5862 mL
80 mM 0.0476 mL 0.2379 mL 0.4758 mL 1.1896 mL
100 mM 0.0381 mL 0.1903 mL 0.3807 mL 0.9517 mL
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Clonixin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clonixin17737-65-4SCH-10304SCH10304SCH 10304Othersanalgesicanti-inflammatoryrodentspainnervecompressionInhibitorinhibitorinhibit

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