2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. CM037

CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 μM). CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics.

For research use only. We do not sell to patients.

CM037 Chemical Structure

CM037 Chemical Structure

CAS No. : 896795-60-1

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Based on 1 publication(s) in Google Scholar

CM037 Related Antibodies

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ALDH1 ALDH2 ALDH3

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Description

CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 μM). CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics[1][2].

IC50 & Target

ALDH1

 

Cellular Effect
Cell Line Type Value Description References
OV-90 EC50
3.96 μM
Compound: 2
Cytotoxicity against 3D culture of human OV90 cells assessed as decrease in cell viability after 6 days by CellTiter-Glo assay
Cytotoxicity against 3D culture of human OV90 cells assessed as decrease in cell viability after 6 days by CellTiter-Glo assay
[PMID: 29767973]
In Vitro

Cell viability and VEGF release experiments: CM037 (10 μM; 18 h) dose-dependently downregulates the expression and secretion of VEGF in MCF-7 cells and inhibited the proliferation and migration of endothelial cells[2].
Western blot experiment: CM037 (1 μM, 10 μM; 18 h) significantly reduces the levels of HIF-1α and VEGF proteins and blocked the RA/RAR signaling pathway[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CM037 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 breast cancer cells
Concentration: 1-10 μM
Incubation Time: 18-48 h
Result: Dose-dependently reduced VEGF secretion (ELISA) and HIF-1α expression (WB) in MCF-7 cells, without significant cytotoxicity (MTT assay).

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1 μM
Incubation Time: 48 h
Result: Decreased phosphorylated RARα and HIF-1α protein levels, concurrent with reduced VEGF expression, indicating inhibition of RA/RAR-mediated angiogenic signaling.
Molecular Weight

431.57

Formula

C21H25N3O3S2
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C1C2=C(N=C(SCC(OCC)=O)N1CCCN3CCCC3)C4=CC=CC=C4S2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (193.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3171 mL 11.5856 mL 23.1712 mL
5 mM 0.4634 mL 2.3171 mL 4.6342 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.55%

SDS (393 KB)

COA (249 KB) HNMR (265 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3171 mL 11.5856 mL 23.1712 mL 57.9280 mL
5 mM 0.4634 mL 2.3171 mL 4.6342 mL 11.5856 mL
10 mM 0.2317 mL 1.1586 mL 2.3171 mL 5.7928 mL
15 mM 0.1545 mL 0.7724 mL 1.5447 mL 3.8619 mL
20 mM 0.1159 mL 0.5793 mL 1.1586 mL 2.8964 mL
25 mM 0.0927 mL 0.4634 mL 0.9268 mL 2.3171 mL
30 mM 0.0772 mL 0.3862 mL 0.7724 mL 1.9309 mL
40 mM 0.0579 mL 0.2896 mL 0.5793 mL 1.4482 mL
50 mM 0.0463 mL 0.2317 mL 0.4634 mL 1.1586 mL
60 mM 0.0386 mL 0.1931 mL 0.3862 mL 0.9655 mL
80 mM 0.0290 mL 0.1448 mL 0.2896 mL 0.7241 mL
100 mM 0.0232 mL 0.1159 mL 0.2317 mL 0.5793 mL
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CM037 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CM037896795-60-1A37CM 037CM-037A 37A-37Aldehyde Dehydrogenase (ALDH)Inhibitorinhibitorinhibit

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