CMP-Sialic acid sodium salt (Synonyms: CMP-Neu5Ac sodium salt)

Name: CMP-Sialic acid sodium salt
Brand: MedChemExpress
SKU: HY-112942A
Rating: 4.5 (1 reviews)

Cat. No.: HY-112942A Purity: 92.51%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.

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CMP-Sialic acid sodium salt Chemical Structure

CAS No. : 1007117-62-5

Size	Price	Stock	Quantity
1 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 275	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 576	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

CMP-Sialic acid sodium salt (22.5 μM, 45 min) can be used as a CMAH substrate to detect the formation of Neu5Gc in platelet lysates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

636.43

Formula

C₂₀H₃₀N₄NaO₁₆P

CAS No.

1007117-62-5

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@H](O[C@@H](N2C(N=C(N)C=C2)=O)[C@@H]1O)COP(O[C@@]3(O[C@@]([C@H](NC(C)=O)[C@@H](O)C3)([H])[C@H](O)[C@H](O)CO)C(O)=O)(O[Na])=O

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Shipping with dry ice.

Storage

-80°C

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (196.41 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5713 mL	7.8563 mL	15.7126 mL
5 mM	0.3143 mL	1.5713 mL	3.1425 mL
10 mM	0.1571 mL	0.7856 mL	1.5713 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 92.51%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (253 KB) HNMR (298 KB) RP-HPLC (264 KB)

Handling Instructions (2659 KB)

References

[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5. [Content Brief]

[2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

[3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.5713 mL	7.8563 mL	15.7126 mL	39.2816 mL
	5 mM	0.3143 mL	1.5713 mL	3.1425 mL	7.8563 mL
	10 mM	0.1571 mL	0.7856 mL	1.5713 mL	3.9282 mL
	15 mM	0.1048 mL	0.5238 mL	1.0475 mL	2.6188 mL
	20 mM	0.0786 mL	0.3928 mL	0.7856 mL	1.9641 mL
	25 mM	0.0629 mL	0.3143 mL	0.6285 mL	1.5713 mL
	30 mM	0.0524 mL	0.2619 mL	0.5238 mL	1.3094 mL
	40 mM	0.0393 mL	0.1964 mL	0.3928 mL	0.9820 mL
	50 mM	0.0314 mL	0.1571 mL	0.3143 mL	0.7856 mL
	60 mM	0.0262 mL	0.1309 mL	0.2619 mL	0.6547 mL
	80 mM	0.0196 mL	0.0982 mL	0.1964 mL	0.4910 mL
	100 mM	0.0157 mL	0.0786 mL	0.1571 mL	0.3928 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

CMP-Sialic acid sodium salt Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CMP-Sialic acid1007117-62-5CMP-Neu5AcEndogenous MetaboliteUDP-GlcNAc 2-epimerasesialicacidGolgisialyltransferasessugardonornucleotidesubstrateInhibitorinhibitorinhibit

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CMP-Sialic acid sodium salt (Synonyms: CMP-Neu5Ac sodium salt)

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Complete Stock Solution Preparation Table

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