Corydamine

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Corydamine, 3-arylisoquinoline alkaloid, is a potent DNA topoisomerase I/II inhibitor. Corydamine has anti-cancer activity.

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Corydamine Chemical Structure

CAS No. : 49870-84-0

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

Corydamine, 3-arylisoquinoline alkaloid, is a potent DNA topoisomerase I/II inhibitor. Corydamine has anti-cancer activity^[1].

IC₅₀ & Target^[1]

Topoisomerase I

Topoisomerase II

Cellular Effect

Cell Line	Type	Value	Description	References
BGC-823	IC₅₀	25.92 μM Compound: 1	Antiproliferative activity against human BGC-823 cells after 72 hrs by MTT assay Antiproliferative activity against human BGC-823 cells after 72 hrs by MTT assay	[PMID: 34802836]
HCCLM9	IC₅₀	10.02 μM Compound: 1	Antiproliferative activity against human HCCLM9 cells after 72 hrs by MTT assay Antiproliferative activity against human HCCLM9 cells after 72 hrs by MTT assay	[PMID: 34802836]
HCT-116	IC₅₀	> 150 μM Compound: 1	Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay	[PMID: 34802836]
HepG2	IC₅₀	45 μM Compound: 1	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 34802836]
HGC-27	IC₅₀	20.91 μM Compound: 1	Antiproliferative activity against human HGC-27 cells after 72 hrs by MTT assay Antiproliferative activity against human HGC-27 cells after 72 hrs by MTT assay	[PMID: 34802836]
HL-60	IC₅₀	112.8 μM Compound: 1	Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay	[PMID: 34802836]
HT-29	IC₅₀	23 μM Compound: 1	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 34802836]
Huh-7	IC₅₀	15.51 μM Compound: 1	Antiproliferative activity against human Huh-7 cells after 72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells after 72 hrs by MTT assay	[PMID: 34802836]
L02	IC₅₀	> 150 μM Compound: 1	Antiproliferative activity against human L02 cells after 72 hrs by MTT assay Antiproliferative activity against human L02 cells after 72 hrs by MTT assay	[PMID: 34802836]
MCF7	IC₅₀	49.9 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 34802836]
MDA-MB-231	IC₅₀	19.3 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 34802836]
RKO	IC₅₀	63.5 μM Compound: 1	Antiproliferative activity against human RKO cells after 72 hrs by MTT assay Antiproliferative activity against human RKO cells after 72 hrs by MTT assay	[PMID: 34802836]
SGC-7901	IC₅₀	10620 μM Compound: 1	Antiproliferative activity against human SGC-7901 cells after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells after 72 hrs by MTT assay	[PMID: 34802836]
SK-HEP1	IC₅₀	28.19 μM Compound: 1	Antiproliferative activity against human SK-HEP1 cells after 72 hrs by MTT assay Antiproliferative activity against human SK-HEP1 cells after 72 hrs by MTT assay	[PMID: 34802836]
SW480	IC₅₀	25.4 μM Compound: 1	Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay	[PMID: 34802836]
U-251	IC₅₀	19.1 μM Compound: 1	Antiproliferative activity against human U-251 cells after 72 hrs by MTT assay Antiproliferative activity against human U-251 cells after 72 hrs by MTT assay	[PMID: 34802836]

Molecular Weight

350.37

Formula

C₂₀H₁₈N₂O₄

CAS No.

49870-84-0

SMILES

CNCCC1=C(C2=CC3=C(C=N2)C(OCO4)=C4C=C3)C=C(OCO5)C5=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xuemei Deng, et al. Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids. Eur J Med Chem. 2022 Jan 15;228:113985. [Content Brief]

Corydamine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Corydamine49870-84-0Topoisomerase3-arylisoquinoline alkaloidDNA topoisomerase I/IIInhibitorinhibitorinhibit

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