2. Anti-infection Immunology/Inflammation
  3. Bacterial COX
  4. COX-1/2-IN-9

COX-1/2-IN-9 (Compound 3n) is a potent and selective inhibitor of COX-1/2, with IC50 values of 0.031 µM and 0.01 µM, respectively. COX-1/2-IN-9 possesses both antibacterial and anti-inflammatory activities, effectively inhibiting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). COX-1/2-IN-9 holds significant potential to alleviate MRSA-induced pneumonia in immunocompromised states.

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COX-1/2-IN-9 Chemical Structure

COX-1/2-IN-9 Chemical Structure

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COX-1/2-IN-9 Related Antibodies

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Description

COX-1/2-IN-9 (Compound 3n) is a potent and selective inhibitor of COX-1/2, with IC50 values of 0.031 µM and 0.01 µM, respectively. COX-1/2-IN-9 possesses both antibacterial and anti-inflammatory activities, effectively inhibiting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). COX-1/2-IN-9 holds significant potential to alleviate MRSA-induced pneumonia in immunocompromised states[1].

IC50 & Target

COX-1

0.031 μM (IC50)

COX-2

0.010 μM (IC50)

Molecular Weight

905.57

Formula

C30H20IN9O13S2
SMILES

IC1=CC2=C(N=C(SCC(NC3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)=O)N(C4=CC=C(S(=O)(NCC(NC5=CC=C([N+]([O-])=O)C=C5[N+]([O-])=O)=O)=O)C=C4)C2=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-1/2-IN-9 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-1/2-IN-9BacterialCOXCyclooxygenaseSwiss albino micemethicillin-resistant Staphylococcus aureus (MRSA)pneumoniaantibacterial activitiesanti-inflammatory activitiesInhibitorinhibitorinhibit

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