1. Anti-infection Immunology/Inflammation
  2. Bacterial COX
  3. COX-1/2-IN-9

COX-1/2-IN-9 (Compound 3n) is a potent and selective inhibitor of COX-1/2, with IC50 values of 0.031 µM and 0.01 µM, respectively. COX-1/2-IN-9 possesses both antibacterial and anti-inflammatory activities, effectively inhibiting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). COX-1/2-IN-9 holds significant potential to alleviate MRSA-induced pneumonia in immunocompromised states.

For research use only. We do not sell to patients.

COX-1/2-IN-9 Chemical Structure

COX-1/2-IN-9 Chemical Structure

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Description

COX-1/2-IN-9 (Compound 3n) is a potent and selective inhibitor of COX-1/2, with IC50 values of 0.031 µM and 0.01 µM, respectively. COX-1/2-IN-9 possesses both antibacterial and anti-inflammatory activities, effectively inhibiting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). COX-1/2-IN-9 holds significant potential to alleviate MRSA-induced pneumonia in immunocompromised states[1].

IC50 & Target

COX-1

0.031 μM (IC50)

COX-2

0.010 μM (IC50)

Molecular Weight

905.57

Formula

C30H20IN9O13S2

SMILES

IC1=CC2=C(N=C(SCC(NC3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)=O)N(C4=CC=C(S(=O)(NCC(NC5=CC=C([N+]([O-])=O)C=C5[N+]([O-])=O)=O)=O)C=C4)C2=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
COX-1/2-IN-9
Cat. No.:
HY-162761
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