2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. CP-10

CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6.

For research use only. We do not sell to patients.

CP-10 Chemical Structure

CP-10 Chemical Structure

CAS No. : 2366268-80-4

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1 mg USD 352 In-stock
5 mg USD 880 In-stock
10 mg USD 1250 In-stock
50 mg USD 2650 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

CP-10 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CP-10

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1].

IC50 & Target[1]

CDK6

2.1 nM (DC50)

Cereblon

 

Cellular Effect
Cell Line Type Value Description References
MM1.S IC50
10 nM
Compound: CP-10
Antiproliferative activity against human MM1S cells after 84 hrs by CCK8 assay
Antiproliferative activity against human MM1S cells after 84 hrs by CCK8 assay
[PMID: 31330105]
In Vitro

CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold)[1].
CP-10 displays a cell inhibition potential in multiple myeloma cell MM.1S (IC50≈10 nM) and mantle cell lymphoma cells (in Mino, IC50≈8 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP-10 Related Antibodies
Molecular Weight

871.94

Formula

C44H49N13O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C(C1=O)=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCOCCNC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)N=N5)CC4)C=N3)N=C2N1C9CCCC9)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (229.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1469 mL 5.7343 mL 11.4687 mL
5 mM 0.2294 mL 1.1469 mL 2.2937 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1469 mL 5.7343 mL 11.4687 mL 28.6717 mL
5 mM 0.2294 mL 1.1469 mL 2.2937 mL 5.7343 mL
10 mM 0.1147 mL 0.5734 mL 1.1469 mL 2.8672 mL
15 mM 0.0765 mL 0.3823 mL 0.7646 mL 1.9114 mL
20 mM 0.0573 mL 0.2867 mL 0.5734 mL 1.4336 mL
25 mM 0.0459 mL 0.2294 mL 0.4587 mL 1.1469 mL
30 mM 0.0382 mL 0.1911 mL 0.3823 mL 0.9557 mL
40 mM 0.0287 mL 0.1434 mL 0.2867 mL 0.7168 mL
50 mM 0.0229 mL 0.1147 mL 0.2294 mL 0.5734 mL
60 mM 0.0191 mL 0.0956 mL 0.1911 mL 0.4779 mL
80 mM 0.0143 mL 0.0717 mL 0.1434 mL 0.3584 mL
100 mM 0.0115 mL 0.0573 mL 0.1147 mL 0.2867 mL
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CP-10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-102366268-80-4CP10CP 10PROTACsCDKCyclin dependent kinaseInhibitorinhibitorinhibit

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